• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-HP1alpha antibody :: anti-Human HP1alpha Antibody

Scan QR to view Datasheet
Catalog # MBS854605
Unit / Price
  0.1 mg  /  $215 +1 FREE 8GB USB
Product Name

HP1alpha, Antibody

Full Product Name

HP1alpha (Ab-92) Antibody

Product Synonym Names
antigen p25; chromobox protein homolog 5; heterochromatin protein 1 alpha; HP1 alpha; HP1A
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
604478
3D Structure
ModBase 3D Structure for P45973
Species Reactivity
Human
Specificity
HP1alpha (Ab-92) antibody detects endogenous levels of total HP1alpha protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized non-phosphopeptide derived from human HP1alpha around the phosphorylation site of serine 92 (R-K-SP-N-F).
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-HP1alpha antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-HP1alpha antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-HP1alpha antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:1000

Testing Data of anti-HP1alpha antibody
Peptide-+
anti-HP1alpha antibody Testing Data image
Immunohistochemistry (IHC) of anti-HP1alpha antibody
Immunohistochemistry analysis of paraffin-embedded human braina tissue using HP1alpha (Ab-92) antibody. Western blot analysis of extracts from Jurkat cells, treated with insulin (0.01U/ml, 15mins), using HP1alpha (Ab-92) antibody.
anti-HP1alpha antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for HP1alpha. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,225 Da
NCBI Official Full Name
chromobox protein homolog 5
NCBI Official Synonym Full Names
chromobox 5
NCBI Official Symbol
NCBI Official Synonym Symbols
HP1; HP1A; HEL25
  [Similar Products]
NCBI Protein Information
chromobox protein homolog 5
UniProt Protein Name
Chromobox protein homolog 5
UniProt Synonym Protein Names
Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha
UniProt Gene Name
UniProt Synonym Gene Names
HP1A; HP1 alpha  [Similar Products]
NCBI Summary for HP1alpha
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for HP1alpha
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Product References and Citations for anti-HP1alpha antibody
Saunders W.S., J. Cell Sci. 104:573-582(1993). The MGC Project Team; Genome Res. 14:2121-2127(2004). Ye Q., J. Biol. Chem. 271:14653-14656(1996).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000