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anti-HP1alpha antibody :: anti-Human HP1alpha Antibody

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Catalog # MBS854605
Unit / Price
  0.1 mg  /  $215 +1 FREE 8GB USB
Product Name

HP1alpha, Antibody

Full Product Name

HP1alpha (Ab-92) Antibody

Product Synonym Names
antigen p25; chromobox protein homolog 5; heterochromatin protein 1 alpha; HP1 alpha; HP1A
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P45973
Species Reactivity
HP1alpha (Ab-92) antibody detects endogenous levels of total HP1alpha protein.
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
The antiserum was produced against synthesized non-phosphopeptide derived from human HP1alpha around the phosphorylation site of serine 92 (R-K-SP-N-F).
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-HP1alpha antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-HP1alpha antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-HP1alpha antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:1000

Testing Data of anti-HP1alpha antibody
anti-HP1alpha antibody Testing Data image
Immunohistochemistry (IHC) of anti-HP1alpha antibody
Immunohistochemistry analysis of paraffin-embedded human braina tissue using HP1alpha (Ab-92) antibody. Western blot analysis of extracts from Jurkat cells, treated with insulin (0.01U/ml, 15mins), using HP1alpha (Ab-92) antibody.
anti-HP1alpha antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for HP1alpha. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,225 Da
NCBI Official Full Name
chromobox protein homolog 5
NCBI Official Synonym Full Names
chromobox 5
NCBI Official Symbol
NCBI Official Synonym Symbols
HP1; HP1A; HEL25
  [Similar Products]
NCBI Protein Information
chromobox protein homolog 5
UniProt Protein Name
Chromobox protein homolog 5
UniProt Synonym Protein Names
Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha
UniProt Gene Name
UniProt Synonym Gene Names
HP1A; HP1 alpha  [Similar Products]
NCBI Summary for HP1alpha
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for HP1alpha
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Product References and Citations for anti-HP1alpha antibody
Saunders W.S., J. Cell Sci. 104:573-582(1993). The MGC Project Team; Genome Res. 14:2121-2127(2004). Ye Q., J. Biol. Chem. 271:14653-14656(1996).

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