NP_058929.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,112 Da
NCBI Official Full Name
4-hydroxyphenylpyruvate dioxygenase
NCBI Official Synonym Full Names
4-hydroxyphenylpyruvate dioxygenase
NCBI Protein Information
4-hydroxyphenylpyruvate dioxygenase
UniProt Protein Name
4-hydroxyphenylpyruvate dioxygenase
UniProt Synonym Protein Names
4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; F Alloantigen; F protein
UniProt Synonym Gene Names
NCBI Summary for HPD
catalyzes the conversion of 4-hydroxyphenylpyruvate to homogenistate in tyrosine catabolism [RGD, Feb 2006]
UniProt Comments for HPD
HPD: Key enzyme in the degradation of tyrosine. Defects in HPD are the cause of tyrosinemia type 3 (TYRO3). TYRO3 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation. Defects in HPD are a cause of hawkinsinuria (HAWK). HAWK is an inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine. Belongs to the 4HPPD family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; EC 1.13.11.27; Oxidoreductase
Chromosomal Location of Human Ortholog: 12q16
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane
Molecular Function: 4-hydroxyphenylpyruvate dioxygenase activity; metal ion binding
Biological Process: L-phenylalanine catabolic process; tyrosine catabolic process
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Pathways associated with HPD elisa kit
Diseases associated with HPD elisa kit
Organs/Tissues associated with HPD elisa kit
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