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HSD17B11 recombinant protein :: Hydroxysteroid Dehydrogenase 11 Recombinant Protein

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Catalog # MBS144293
Unit / Price
  0.005 mg  /  $140 +1 FREE 8GB USB
  0.02 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $3,515 +4 FREE 8GB USB
HSD17B11 recombinant protein
Product Name

Hydroxysteroid Dehydrogenase 11 (HSD17B11), Recombinant Protein

Full Product Name

Recombinant Human Hydroxysteroid (17-beta) Dehydrogenase 11

Product Synonym Names
HSD17B11 Human; Hydroxysteroid (17-beta) Dehydrogenase 11 Human Recombinant; Estradiol 17-beta-dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; CTCL-associated antigen HD-CL-03; Dehydrogenase/reductase SDR family member 8; Retinal short-chain dehydrogenase/reductase 2; retSDR2; HSD17B11; DHRS8; PAN1B; SDR16C2; 17BHSD11
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHH HHH SSGLVPRGSH MESFVK LFIP KRRKSVTGEI VLITGAGHGI GRLTAYEFAK LKSKLVLWDI NKHGLEETAA KCKGLGAKVH TFVVDCSNRE DIYSSAKKVK AEIGDVSILV NNAGVVYTSD LFATQDPQIE KTFEVNVLAH FWTTKAFLPA MTKNNHGHIV TVASAAGHVS VPFLLAYCSS KFAAVGFHKT LTDELAALQI TGVKTTCLCP NFVNTGFIKN PSTSLGPTLE PEEVVNRLMH GILTEQKMIF IPSSIAFLTT LERILPERFL AVLKQKI
OMIM
612831
3D Structure
ModBase 3D Structure for Q8NBQ5
Host
E Coli
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Form/Format
The HSD17B11 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT and 20% glycerol.
Sterile Filtered colorless solution.
Preparation and Storage
HSD17B11 should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Other Notes
Small volumes of HSD17B11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
HSD17B11 recombinant protein
Description: HSD17B11 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 287 amino acids (20-285 a.a.) and having a molecular mass of 31.4kDa. The HSD17B11 is purified by proprietary chromatographic techniques.

Introduction: Dehydrogenase/reductase SDR family member 8 (HSD17B11) is a member of the HSD17B family of proteins, which regulate the availability of steroids within various tissues throughout the body. HSD17B11 is widely expressed with the highest levels found in the retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart as well as in steroidogenic cells. HSD17B11 converts androstan-3-?,17-?-diol (3-?-diol) to androsterone, suggesting it may participate in androgen metabolism during steroidogenesis.
NCBI/Uniprot data below describe general gene information for HSD17B11. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,936 Da
NCBI Official Full Name
estradiol 17-beta-dehydrogenase 11
NCBI Official Synonym Full Names
hydroxysteroid (17-beta) dehydrogenase 11
NCBI Official Symbol
HSD17B11  [Similar Products]
NCBI Official Synonym Symbols
DHRS8; PAN1B; RETSDR2; SDR16C2; 17BHSD11; 17-BETA-HSD11; 17-BETA-HSDXI
  [Similar Products]
NCBI Protein Information
estradiol 17-beta-dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase type XI; CTCL tumor antigen HD-CL-03; CTCL-associated antigen HD-CL-03; cutaneous T-cell lymphoma-associated antigen HD-CL-03; dehydrogenase/reductase SDR family member 8; retinal short-chain dehydrogenase/reductase 2; short chain dehydrogenase/reductase family 16C, member 2
UniProt Protein Name
Estradiol 17-beta-dehydrogenase 11
UniProt Synonym Protein Names
17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; CTCL-associated antigen HD-CL-03; Dehydrogenase/reductase SDR family member 8; Retinal short-chain dehydrogenase/reductase 2; retSDR2
UniProt Gene Name
HSD17B11  [Similar Products]
UniProt Synonym Gene Names
DHRS8; PAN1B; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-HSD XI; 17betaHSDXI; CTCL-associated antigen HD-CL-03; retSDR2  [Similar Products]
UniProt Entry Name
DHB11_HUMAN
NCBI Summary for HSD17B11
Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]
UniProt Comments for HSD17B11
HSD17B11: Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Protein type: EC 1.1.1.62; Secreted; Oxidoreductase; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: cytoplasm; extracellular region; lipid particle

Molecular Function: estradiol 17-beta-dehydrogenase activity; steroid dehydrogenase activity

Biological Process: steroid biosynthetic process; androgen catabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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