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HSPA5 recombinant protein :: 78 kDa glucose-regulated protein (HSPA5) Recombinant Protein

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Catalog # MBS948259
Unit / Price
Scan QR to view Datasheet
  0.05 mg (E-Coli)  /  $1,060 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $1,090 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,330 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,430 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,485 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,570 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,580 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,685 +2 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,920 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,395 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,485 +3 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,510 +3 FREE 8GB USB
  1 mg (Yeast)  /  $2,655 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,820 +4 FREE 8GB USB
HSPA5 recombinant protein
Product Name

78 kDa glucose-regulated protein (HSPA5), Recombinant Protein

Full Product Name

Recombinant Human 78 kDa glucose-regulated protein (HSPA5)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
19-654. Full Length of Mature Protein
Sequence
EEEDKKEDVG TVVGIDLGTT YSCVGVFKNG RVEIIANDQG NRITPSYVAF TPEGERLIGD AAKNQLTSNP ENTVFDAKRL IGRTWNDPSV QQDIKFLPFK VVEKKTKPYI QVDIGGGQTK TFAPEEISAM VLTKMKETAE AYLGKKVTHA VVTVPAYFND AQRQATKDAG TIAGLNVMRI INEPTAAAIA YGLDKREGEK NILVFDLGGG TFDVSLLTID NGVFEVVATN GDTHLGGEDF DQRVMEHFIK LYKKKTGKDV RKDNRAVQKL RREVEKAKRA LSSQHQARIE IESFYEGEDF SETLTRAKFE ELNMDLFRST MKPVQKVLED SDLKKSDIDE IVLVGGSTRI PKIQQLVKEF FNGKEPSRGI NPDEAVAYGA AVQAGVLSGD QDTGDLVLLD VCPLTLGIET VGGVMTKLIP RNTVVPTKKS QIFSTASDNQ PTVTIKVYEG ERPLTKDNHL LGTFDLTGIP PAPRGVPQIE VTFEIDVNGI LRVTAEDKGT GNKNKITITN DQNRLTPEEI ERMVNDAEKF AEEDKKLKER IDTRNELESY AYSLKNQIGD KEKLGGKLSS EDKETMEKAV EEKIEWLESH QDADIEDFKA KKKELEEIVQ PIISKLYGSA GPPPTGEEDT AEKDEL
OMIM
138120
3D Structure
ModBase 3D Structure for P11021
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of HSPA5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for HSPA5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
72,333 Da
NCBI Official Full Name
78 kDa glucose-regulated protein
NCBI Official Synonym Full Names
heat shock protein family A (Hsp70) member 5
NCBI Official Symbol
HSPA5  [Similar Products]
NCBI Official Synonym Symbols
BIP; MIF2; GRP78; HEL-S-89n
  [Similar Products]
NCBI Protein Information
78 kDa glucose-regulated protein
UniProt Protein Name
Endoplasmic reticulum chaperone BiP
UniProt Synonym Protein Names
78 kDa glucose-regulated protein
UniProt Gene Name
HSPA5  [Similar Products]
UniProt Synonym Gene Names
HSP70 family protein 5Curated  [Similar Products]
NCBI Summary for HSPA5
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]
UniProt Comments for HSPA5
Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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