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HSPG2 recombinant protein :: Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2) Recombinant Protein

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Catalog # MBS953064
Unit / Price
  0.5 mg (E-Coli)  /  $980 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $980 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,200 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,200 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,425 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,425 +1 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,885 +2 FREE 8GB USB
  1 mg (Yeast)  /  $1,885 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,920 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,810 +3 FREE 8GB USB
HSPG2 recombinant protein
Product Name

Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2), Recombinant Protein

Also Known As

Recombinant Human Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2), partial

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
4197-4391. Partial, provide the full length of LG3 peptide chain.
Sequence Length
4391
Sequence
DAPGQYGAYF HDDGFLAFPG HVFSRSLPEV PETIELEVRT STASGLLLWQ GVEVGEAGQG KDFISLGLQD GHLVFRYQLG SGEARLVSED PINDGEWHRV TALREGRRGS IQVDGEELVS GRSPGPNVAV NAKGSVYIGG APDVATLTGG RFSSGITGCV KNLVLHSARP GAPPPQPLDL QHRAQAGANT RPCPS
OMIM
142461
3D Structure
ModBase 3D Structure for P98160
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of HSPG2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for HSPG2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
468,830 Da
NCBI Official Full Name
basement membrane-specific heparan sulfate proteoglycan core protein isoform a
NCBI Official Synonym Full Names
heparan sulfate proteoglycan 2
NCBI Official Symbol
HSPG2  [Similar Products]
NCBI Official Synonym Symbols
PLC; SJA; SJS; HSPG; SJS1; PRCAN
  [Similar Products]
NCBI Protein Information
basement membrane-specific heparan sulfate proteoglycan core protein
UniProt Protein Name
Basement membrane-specific heparan sulfate proteoglycan core protein
UniProt Synonym Protein Names
Perlecan; PLC
UniProt Gene Name
HSPG2  [Similar Products]
UniProt Synonym Gene Names
HSPG; PLC  [Similar Products]
NCBI Summary for HSPG2
This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Comments for HSPG2
Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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