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HTR2A elisa kit :: Human 5 hydroxytryptamine receptor 2A (HTR2A) ELISA Kit

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Catalog # MBS7215991
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HTR2A elisa kit
Product Name

5 hydroxytryptamine receptor 2A (HTR2A), ELISA Kit

Full Product Name

Human 5 hydroxytryptamine receptor 2A (HTR2A) ELISA Kit

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
182135
Species Reactivity
Samples
Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
Assay Type
Competitive
Detection Range
0.5-10ng/mL
Sensitivity
0.1ng/mL
Preparation and Storage
Store all reagents at 2-8 degree C.
Sample Preparation
We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of HTR2A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for HTR2Apurchase
MBS7215991 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 5 hydroxytryptamine receptor 2A (HTR2A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HTR2A. The ELISA analytical biochemical technique of the MBS7215991 kit is based on HTR2A antibody-HTR2A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HTR2A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HTR2A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for HTR2A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,940 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 2A
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
NCBI Official Symbol
HTR2A  [Similar Products]
NCBI Official Synonym Symbols
HTR2; 5-HT2A
  [Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT2 receptor; serotonin 5-HT-2A receptor
UniProt Protein Name
5-hydroxytryptamine receptor 2A
UniProt Synonym Protein Names
Serotonin receptor 2A
UniProt Gene Name
HTR2A  [Similar Products]
UniProt Synonym Gene Names
HTR2; 5-HT-2; 5-HT-2A  [Similar Products]
UniProt Entry Name
5HT2A_HUMAN
NCBI Summary for HTR2A
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for HTR2A
5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 13q14-q21

Cellular Component: cell soma; axon; integral to plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane; dendritic shaft; caveola; cytosol

Molecular Function: serotonin binding; serotonin receptor activity; protein complex binding; G-protein alpha-subunit binding; drug binding

Biological Process: cell death; urinary bladder smooth muscle contraction; phosphoinositide 3-kinase cascade; negative regulation of potassium ion transport; thermoregulation; regulation of dopamine secretion; positive regulation of MAP kinase activity; synaptic transmission; behavioral response to cocaine; positive regulation of cell proliferation; detection of temperature stimulus involved in sensory perception of pain; artery smooth muscle contraction; serotonin receptor signaling pathway; regulation of behavior; aging; response to drug; serotonin receptor, phospholipase C activating pathway; negative regulation of synaptic transmission, glutamatergic; regulation of hormone secretion; sleep; positive regulation of phosphatidylinositol biosynthetic process; memory; cellular calcium ion homeostasis; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of peptidyl-tyrosine phosphorylation; phospholipase C activation; release of sequestered calcium ion into cytosol; positive regulation of glycolysis; positive regulation of vasoconstriction; positive regulation of fat cell differentiation

Disease: Schizophrenia; Alcohol Dependence; Anorexia Nervosa, Susceptibility To, 1; Obsessive-compulsive Disorder; Major Depressive Disorder
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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