NP_113909.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
51,330 Da
NCBI Official Full Name
serine protease HTRA1
NCBI Official Synonym Full Names
HtrA serine peptidase 1
NCBI Official Synonym Symbols
NCBI Protein Information
serine protease HTRA1
UniProt Protein Name
Serine protease HTRA1
UniProt Synonym Protein Names
High-temperature requirement A serine peptidase 1; Serine protease 11
UniProt Synonym Gene Names
UniProt Entry Name
HTRA1_RAT
NCBI Summary for HTRA1
mouse homolog is a serine protease; acts as a inhibitor of Tgf-beta family members [RGD, Feb 2006]
UniProt Comments for HTRA1
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ().
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Products associated with HTRA1 sirna
Diseases associated with HTRA1 sirna
Organs/Tissues associated with HTRA1 sirna
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