NP_057485.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
protein Hikeshi isoform 1
NCBI Official Synonym Full Names
Hikeshi, heat shock protein nuclear import factor
NCBI Official Synonym Symbols
HLD13; L7RN6; OPI10; HSPC138; HSPC179; C11orf73 [Similar Products]
NCBI Protein Information
protein Hikeshi
UniProt Protein Name
Protein Hikeshi
UniProt Entry Name
HIKES_HUMAN
NCBI Summary for C11orf73
This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress. [provided by RefSeq, Apr 2016]
UniProt Comments for C11orf73
C11orf73: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus
Protein type: Cell development/differentiation
Chromosomal Location of Human Ortholog: 11q14.2
Cellular Component: intracellular; cell junction; cytosol; nucleus
Molecular Function: Hsp70 protein binding; protein transporter activity
Biological Process: protein transport; protein import into nucleus; Golgi organization and biogenesis; lung development
Research Articles on C11orf73
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Pathways associated with C11orf73 elisa kit
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