CAJ18415.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
32,897 Da
NCBI Official Full Name
Ccnd2
NCBI Official Synonym Full Names
cyclin D2
NCBI Official Synonym Symbols
cD2; Vin1; Vin-1; C86853; AI256817; BF642806; 2600016F06Rik [Similar Products]
NCBI Protein Information
G1/S-specific cyclin-D2
UniProt Protein Name
Ccnd2 protein
UniProt Synonym Protein Names
Ccnd2 protein
UniProt Entry Name
Q4FK45_MOUSE
UniProt Comments for CCND2
CCND2: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/p27Kip1, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/p27Kip1 required for nuclear translocation and modulation of CDK4-mediated kinase activity. Belongs to the cyclin family. Cyclin D subfamily.
Protein type: Motility/polarity/chemotaxis; Cell cycle regulation
Cellular Component: nucleoplasm; nuclear membrane; membrane; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; nucleolus; cytosol; nucleus; chromatin
Molecular Function: protein binding; protein kinase binding
Biological Process: positive regulation of cyclin-dependent protein kinase activity; cell division; regulation of cell cycle; positive regulation of cell proliferation; regulation of cyclin-dependent protein kinase activity; positive regulation of protein amino acid phosphorylation; cell cycle; positive regulation of epithelial cell proliferation; G1/S transition of mitotic cell cycle
Research Articles on CCND2
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Pathways associated with CCND2 elisa kit
Diseases associated with CCND2 elisa kit
Organs/Tissues associated with CCND2 elisa kit
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