NP_000774.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,558 Da
NCBI Official Full Name
cytochrome P450 26A1 isoform 1
NCBI Official Synonym Full Names
cytochrome P450, family 26, subfamily A, polypeptide 1
NCBI Protein Information
cytochrome P450 26A1; hP450RAI; cytochrome P450RAI; retinoic acid 4-hydroxylase; P450, retinoic acid-inactivating, 1; retinoic acid-metabolizing cytochrome; cytochrome P450 retinoic acid-inactivating 1; cytochrome P450, subfamily XXVIA, polypeptide 1
UniProt Protein Name
Cytochrome P450 26A1
UniProt Synonym Protein Names
Cytochrome P450 retinoic acid-inactivating 1; Cytochrome P450RAI; hP450RAI; Retinoic acid 4-hydroxylase; Retinoic acid-metabolizing cytochrome
UniProt Synonym Gene Names
UniProt Entry Name
CP26A_HUMAN
NCBI Summary for CYP26A1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP26A1
CYP26A1: Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. Belongs to the cytochrome P450 family.
Protein type: Cofactor and Vitamin Metabolism - retinol; Oxidoreductase; EC 1.14.-.-; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 10q23-q24
Cellular Component: endoplasmic reticulum membrane
Molecular Function: retinoic acid binding; iron ion binding; retinoic acid 4-hydroxylase activity; heme binding; oxygen binding
Biological Process: anterior/posterior pattern formation; retinoic acid receptor signaling pathway; negative regulation of retinoic acid receptor signaling pathway; central nervous system development; vitamin metabolic process; neural crest cell development; metabolic process; xenobiotic metabolic process
Research Articles on CYP26A1
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Products associated with CYP26A1 elisa kit
Pathways associated with CYP26A1 elisa kit
Diseases associated with CYP26A1 elisa kit
Organs/Tissues associated with CYP26A1 elisa kit
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