NP_001161362.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,388 Da
NCBI Official Full Name
epidermal growth factor-like protein 6 isoform 2
NCBI Official Synonym Full Names
EGF-like-domain, multiple 6
NCBI Official Synonym Symbols
NCBI Protein Information
epidermal growth factor-like protein 6
UniProt Protein Name
Epidermal growth factor-like protein 6
UniProt Synonym Protein Names
MAM and EGF domains-containing gene protein
UniProt Synonym Gene Names
UniProt Entry Name
EGFL6_HUMAN
NCBI Summary for EGFL6
This gene encodes a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. The gene product contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. [provided by RefSeq, Jul 2008]
UniProt Comments for EGFL6
EGFL6: May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly. Belongs to the nephronectin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: Xp22
Cellular Component: extracellular space; membrane; basement membrane
Molecular Function: integrin binding; calcium ion binding
Biological Process: extracellular matrix organization and biogenesis; multicellular organismal development; cell cycle; cell adhesion; cell differentiation
Research Articles on EGFL6
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Diseases associated with EGFL6 elisa kit
Organs/Tissues associated with EGFL6 elisa kit
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