AAK91714.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,635 Da
NCBI Official Full Name
pannexin 1
NCBI Official Synonym Full Names
pannexin 1
NCBI Protein Information
pannexin-1
UniProt Protein Name
Pannexin-1
UniProt Synonym Gene Names
UniProt Entry Name
PANX1_HUMAN
NCBI Summary for PANX1
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]
UniProt Comments for PANX1
PANX1: Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. Belongs to the pannexin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 11q21
Cellular Component: endoplasmic reticulum membrane; protein complex; membrane; endoplasmic reticulum; integral to membrane; gap junction; plasma membrane
Molecular Function: actin filament binding; protease binding; leak channel activity; protein heterodimerization activity; calcium channel activity; gap junction hemi-channel activity; receptor binding
Biological Process: positive regulation of interleukin-1 alpha secretion; synaptic transmission; calcium ion transport; innate immune response; positive regulation of interleukin-1 beta secretion; cation transport; response to ATP
Research Articles on PANX1
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Products associated with PANX1 elisa kit
Pathways associated with PANX1 elisa kit
Diseases associated with PANX1 elisa kit
Organs/Tissues associated with PANX1 elisa kit
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