NP_001308661.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,838 Da
NCBI Official Full Name
probable ATP-dependent RNA helicase DDX41 isoform 2
NCBI Official Synonym Full Names
DEAD-box helicase 41
NCBI Official Synonym Symbols
NCBI Protein Information
probable ATP-dependent RNA helicase DDX41
UniProt Protein Name
Probable ATP-dependent RNA helicase DDX41
UniProt Synonym Protein Names
DEAD box protein 41; DEAD box protein abstrakt homolog
UniProt Synonym Gene Names
NCBI Summary for DDX41
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. [provided by RefSeq, Jan 2017]
UniProt Comments for DDX41
DDX41: Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing. Belongs to the DEAD box helicase family. DDX41 subfamily.
Protein type: EC 3.6.4.13; Helicase; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: catalytic step 2 spliceosome; cytoplasm; cytosol; endoplasmic reticulum; membrane; nucleolus; nucleus; spliceosomal complex
Molecular Function: ATP binding; ATP-dependent RNA helicase activity; DNA binding; metal ion binding; protein binding; RNA binding
Biological Process: apoptosis; cell differentiation; cell proliferation; defense response to virus; mRNA splicing, via spliceosome; positive regulation of interferon type I production; positive regulation of transcription from RNA polymerase II promoter; regulation of type I interferon production; RNA secondary structure unwinding
Disease: Myeloproliferative/lymphoproliferative Neoplasms, Familial (multiple Types), Susceptibility To
Research Articles on DDX41
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Products associated with DDX41 elisa kit
Pathways associated with DDX41 elisa kit
Diseases associated with DDX41 elisa kit
Organs/Tissues associated with DDX41 elisa kit
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