NP_001005290.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,981 Da
NCBI Official Full Name
proline/serine-rich coiled-coil protein 1 isoform b
NCBI Official Synonym Full Names
proline/serine-rich coiled-coil 1
NCBI Official Synonym Symbols
NCBI Protein Information
proline/serine-rich coiled-coil protein 1
UniProt Protein Name
Proline/serine-rich coiled-coil protein 1
UniProt Synonym Gene Names
UniProt Entry Name
PSRC1_HUMAN
NCBI Summary for PSRC1
This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]
UniProt Comments for PSRC1
PSRC1: Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. Belongs to the PSRC1 family. 4 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: microtubule cytoskeleton; nucleoplasm; spindle pole; spindle microtubule; cytoplasm; spindle; midbody; cytosol
Molecular Function: protein binding; microtubule binding
Biological Process: positive regulation of cyclin-dependent protein kinase activity; cell division; positive regulation of transcription, DNA-dependent; positive regulation of microtubule polymerization; negative regulation of cell growth; mitotic metaphase plate congression; microtubule bundle formation
Research Articles on PSRC1
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Products associated with PSRC1 elisa kit
Diseases associated with PSRC1 elisa kit
Organs/Tissues associated with PSRC1 elisa kit
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