P05412.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Transcription factor AP-1
NCBI Official Synonym Full Names
jun proto-oncogene
NCBI Protein Information
transcription factor AP-1; p39; jun oncogene; activator protein 1; proto-oncogene c-Jun; enhancer-binding protein AP1; Jun activation domain binding protein; v-jun sarcoma virus 17 oncogene homolog; v-jun avian sarcoma virus 17 oncogene homolog
UniProt Protein Name
Transcription factor AP-1
UniProt Synonym Protein Names
Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39
UniProt Synonym Gene Names
UniProt Entry Name
JUN_HUMAN
NCBI Summary for Jun
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
UniProt Comments for Jun
Jun: the protooncogene c-Jun is a component of the transcription factor AP-1, which binds and activates transcription at TRE/AP-1 elements. The Jun Kinases (JNKs) binds to the N-terminal region of c-Jun and phosphorylate it in response to extracellular signals including growth factors, cytokines and stress, regulating its transcriptional activity.
Protein type: Transcription factor; Oncoprotein
Chromosomal Location of Human Ortholog: 1p32-p31
Cellular Component: nucleoplasm; nuclear chromosome; transcription factor complex; transcriptional repressor complex; nucleus; cytosol
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; DNA binding; transcription coactivator activity; double-stranded DNA binding; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; positive regulation of monocyte differentiation; circadian rhythm; response to cAMP; regulation of cell cycle; positive regulation of transcription, DNA-dependent; positive regulation of smooth muscle cell proliferation; stress-activated MAPK cascade; microglial cell activation; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; SMAD protein nuclear translocation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; negative regulation of cell proliferation; positive regulation of fibroblast proliferation; response to radiation; regulation of transcription factor activity; positive regulation of neuron apoptosis; transforming growth factor beta receptor signaling pathway; negative regulation of protein amino acid autophosphorylation; negative regulation of neuron apoptosis; angiogenesis; toll-like receptor 4 signaling pathway; aging; response to drug; release of cytochrome c from mitochondria; monocyte differentiation; leading edge cell differentiation; MyD88-independent toll-like receptor signaling pathway; axon regeneration; learning; liver development; negative regulation of DNA binding; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; membrane depolarization; cellular response to potassium ion starvation; response to hydrogen peroxide; response to mechanical stimulus; response to cytokine stimulus; toll-like receptor signaling pathway; innate immune response; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; negative regulation of transcription, DNA-dependent; positive regulation of DNA replication
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Products associated with anti-Jun antibody
Pathways associated with anti-Jun antibody
Diseases associated with anti-Jun antibody
Organs/Tissues associated with anti-Jun antibody
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