NP_000764.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cytochrome P450 2E1
NCBI Official Synonym Full Names
cytochrome P450 family 2 subfamily E member 1
NCBI Protein Information
cytochrome P450 2E1
UniProt Protein Name
Cytochrome P450 2E1
UniProt Synonym Protein Names
4-nitrophenol 2-hydroxylase (EC:1.14.13.n7); CYPIIE1; Cytochrome P450-J
UniProt Synonym Gene Names
NCBI Summary for CYP2E1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP2E1
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Research Articles on CYP2E1
Precautions
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Disclaimer
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Products associated with anti-CYP2E1 antibody
Pathways associated with anti-CYP2E1 antibody
Diseases associated with anti-CYP2E1 antibody
Organs/Tissues associated with anti-CYP2E1 antibody
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