NP_000764.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,849 Da
NCBI Official Full Name
cytochrome P450 2E1
NCBI Official Synonym Full Names
cytochrome P450 family 2 subfamily E member 1
NCBI Protein Information
cytochrome P450 2E1
UniProt Protein Name
Cytochrome P450 2E1
UniProt Synonym Protein Names
4-nitrophenol 2-hydroxylase (EC:1.14.13.n7); CYPIIE1; Cytochrome P450-J
UniProt Synonym Gene Names
NCBI Summary for CYP2E1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP2E1
CYP2E1: Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms. Belongs to the cytochrome P450 family.
Protein type: EC 1.14.13.n7; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Mitochondrial; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 10q26.3
Cellular Component: endoplasmic reticulum membrane
Molecular Function: arachidonic acid epoxygenase activity; enzyme binding; heme binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; oxygen binding; steroid hydroxylase activity
Biological Process: benzene metabolic process; carbon tetrachloride metabolic process; drug metabolic process; epoxygenase P450 pathway; halogenated hydrocarbon metabolic process; heterocycle metabolic process; monoterpenoid metabolic process; steroid metabolic process; xenobiotic metabolic process
Research Articles on CYP2E1
Precautions
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Products associated with anti-CYP2E1 antibody
Pathways associated with anti-CYP2E1 antibody
Diseases associated with anti-CYP2E1 antibody
Organs/Tissues associated with anti-CYP2E1 antibody
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