NP_003782.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
117,749 Da
NCBI Official Full Name
membrane-bound transcription factor site-1 protease preproprotein
NCBI Official Synonym Full Names
membrane-bound transcription factor peptidase, site 1
NCBI Protein Information
membrane-bound transcription factor site-1 protease; endopeptidase S1P; subtilisin/kexin isozyme-1
UniProt Protein Name
Membrane-bound transcription factor site-1 protease
UniProt Synonym Protein Names
Endopeptidase S1P; Subtilisin/kexin-isozyme 1
UniProt Synonym Gene Names
UniProt Entry Name
MBTP1_HUMAN
NCBI Summary for MBTPS1
The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein. [provided by RefSeq, Jul 2008]
UniProt Comments for MBTPS1
MBTPS1: Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His- Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Belongs to the peptidase S8 family.
Protein type: EC 3.4.21.112; Membrane protein, integral; Endoplasmic reticulum; Protease
Chromosomal Location of Human Ortholog: 16q24
Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; Golgi stack; endoplasmic reticulum lumen; integral to membrane
Molecular Function: serine-type endopeptidase activity
Biological Process: cholesterol metabolic process; regulation of transcription factor import into nucleus; unfolded protein response, activation of signaling protein activity; membrane protein intracellular domain proteolysis; cellular protein metabolic process; lysosome organization and biogenesis; unfolded protein response; lipid metabolic process; proteolysis
Research Articles on MBTPS1
Precautions
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Pathways associated with anti-MBTPS1 antibody
Diseases associated with anti-MBTPS1 antibody
Organs/Tissues associated with anti-MBTPS1 antibody
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