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KLK3 native protein :: Prostate Specific Antigen (PSA) ACT Complex >95% Pure Native Protein

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Catalog # MBS318602
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KLK3 native protein
Product Name

Prostate Specific Antigen (PSA) ACT Complex >95% Pure (KLK3), Native Protein

Full Product Name

PSA ACT Complex

Product Synonym Names
Prostate Specific Antigen (PSA) ACT Complex >95% Pure
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 19; NC_000019.9 (51358171..51364020). Location: 19q13.41
OMIM
176820
3D Structure
ModBase 3D Structure for P07288
Host
Human Seminal Fluid and Human serum
Species Reactivity
Human
Specificity
Prostate Specific Antigen (PSA) ACT Complex >95% Pure
Purity/Purification
>95% pure (SDS-PAGE). SDS-PAGE shows one band corresponding to a molecular weight of 81 kDa.
Form/Format
Purified, Liquid
Concentration
0.9mg/ml (lot specific)
Inactivation
Not applicable
Buffer
10mM Sodium Acetate buffer, pH 5.6 containing 150mM Sodium chloride
Preservative
No
Warnings
All human source materials have tested negative for HIV1, HIV2, HCV antibodies, HBsAg, HIV-1 Antigen and Syphilis by currently approved FDA methods.. No test guarantees a product to be non-infectious. Therefore, all material derived from human f
Preparation and Storage
Upon receipt, store at -20 degree C. Avoid multiple freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of KLK3 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for KLK3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,741 Da[Similar Products]
NCBI Official Full Name
prostate-specific antigen isoform 1 preproprotein
NCBI Official Synonym Full Names
kallikrein-related peptidase 3
NCBI Official Symbol
NCBI Official Synonym Symbols
APS; PSA; hK3; KLK2A1
  [Similar Products]
NCBI Protein Information
prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen
UniProt Protein Name
Prostate-specific antigen
UniProt Synonym Protein Names
Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
KLK3_HUMAN
NCBI Summary for KLK3
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq]
UniProt Comments for KLK3
Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

Catalytic activity: Preferential cleavage: -Tyr-|-Xaa-.

Enzyme regulation: Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Ref.18

Subcellular location: Secreted.

Sequence similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain.

Sequence caution: The sequence AAD14185.1 differs from that shown. Reason: Erroneous initiation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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