AAD26363.1
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NCBI Official Full Name
vanilloid receptor-like protein 1
NCBI Summary for Vanilloid Receptor Like Protein 1
This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]
UniProt Comments for Vanilloid Receptor Like Protein 1
TRPV2: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: cell surface; integral to plasma membrane; melanosome; plasma membrane; endomembrane system
Molecular Function: calcium channel activity; ion transmembrane transporter activity; ion channel activity; cation channel activity
Biological Process: response to temperature stimulus; response to heat; transport; sensory perception; positive regulation of axon extension; transmembrane transport
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