NP_005612.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
protein S100-A12
NCBI Official Synonym Full Names
S100 calcium binding protein A12
NCBI Official Synonym Symbols
p6; CAGC; CGRP; MRP6; CAAF1; MRP-6; ENRAGE [Similar Products]
NCBI Protein Information
protein S100-A12
UniProt Protein Name
Protein S100-A12
UniProt Synonym Protein Names
CGRP; Calcium-binding protein in amniotic fluid 1; CAAF1
UniProt Synonym Gene Names
UniProt Entry Name
S10AC_HUMAN
NCBI Summary for S100A12
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014]
UniProt Comments for S100A12
S100A12: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. Belongs to the S-101 family.
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: cytoplasm; cytoskeleton; cytosol; extracellular region; nucleus; plasma membrane
Molecular Function: calcium ion binding; copper ion binding; protein binding; RAGE receptor binding; zinc ion binding
Biological Process: activation of NF-kappaB transcription factor; cytokine secretion; defense response to bacterium; defense response to fungus; innate immune response; mast cell activation; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of inflammatory response; positive regulation of MAP kinase activity; xenobiotic metabolic process
Research Articles on S100A12
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Products associated with S100A12 recombinant protein
Pathways associated with S100A12 recombinant protein
Diseases associated with S100A12 recombinant protein
Organs/Tissues associated with S100A12 recombinant protein
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