NP_002007.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
435,170 Da
NCBI Official Full Name
filaggrin
NCBI Official Synonym Full Names
filaggrin
NCBI Official Synonym Symbols
NCBI Protein Information
filaggrin
UniProt Protein Name
Filaggrin
NCBI Summary for FLG
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
UniProt Comments for FLG
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
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Products associated with FLG rtu elisa kit
Pathways associated with FLG rtu elisa kit
Diseases associated with FLG rtu elisa kit
Disease Name |
Pubmed Publications |
Dermatitis, Atopic Antibodies |
>145 publications with FLG and Dermatitis, Atopic |
Dermatitis, Atopic, 1 Antibodies |
>79 publications with FLG and Dermatitis, Atopic, 1 |
Dermatitis, Atopic, 2 Antibodies |
>69 publications with FLG and Dermatitis, Atopic, 2 |
Eczema Antibodies |
>62 publications with FLG and Eczema |
Ichthyosis Antibodies |
>60 publications with FLG and Ichthyosis |
Neoplasms Antibodies |
>58 publications with FLG and Neoplasms |
Ichthyosis Vulgaris Antibodies |
>56 publications with FLG and Ichthyosis Vulgaris |
Lung Diseases Antibodies |
>28 publications with FLG and Lung Diseases |
Inflammation Antibodies |
>23 publications with FLG and Inflammation |
Necrosis Antibodies |
>12 publications with FLG and Necrosis |
Organs/Tissues associated with FLG rtu elisa kit
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