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HYAL1 recombinant protein :: Hyaluronidase-1 Recombinant Protein

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Catalog # MBS1465303
Unit / Price
  0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
  0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
  0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
  0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
  0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,060 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,305 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,345 +1 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,930 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,980 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,545 +3 FREE 8GB USB
SDS-PAGE
Product Name

Hyaluronidase-1 (HYAL1), Recombinant Protein

Popular Item
Also Known As

Recombinant Human Hyaluronidase-1

Product Synonym Names
Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS1465303 COA
Sequence Positions
22-435aa; Full Length
Sequence Length
435
Sequence
FRGPLLPNRP FTTVWNANTQ WCLERHGVDV DVSVFDVVAN PGQTFRGPDM TIFYSSQLGT YPYYTPTGEP VFGGLPQNAS LIAHLARTFQ DILAAIPAPD FSGLAVIDWE AWRPRWAFNW DTKDIYRQRS RALVQAQHPD WPAPQVEAVA QDQFQGAARA WMAGTLQLGR ALRPRGLWGF YGFPDCYNYD FLSPNYTGQC PSGIRAQNDQ LGWLWGQSRA LYPSIYMPAV LEGTGKSQMY VQHRVAEAFR VAVAAGDPNL PVLPYVQIFY DTTNHFLPLD ELEHSLGESA AQGAAGVVLW VSWENTRTKE SCQAIKEYMD TTLGPFILNV TSGALLCSQA LCSGHGRCVR RTSHPKALLL LNPASFSIQL TPGGGPLSLR GALSLEDQAQ MAVEFKCRCY PGWQAPWCER KSMW
OMIM
601492
3D Structure
ModBase 3D Structure for Q12794
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of HYAL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
HYAL1 recombinant protein
May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
Product Categories/Family for HYAL1 recombinant protein

HYAL1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for HYAL1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50.2kD
NCBI Official Full Name
hyaluronidase-1 isoform 1
NCBI Official Synonym Full Names
hyaluronoglucosaminidase 1
NCBI Official Symbol
HYAL1  [Similar Products]
NCBI Official Synonym Symbols
MPS9; NAT6; LUCA1; HYAL-1
  [Similar Products]
NCBI Protein Information
hyaluronidase-1
UniProt Protein Name
Hyaluronidase-1
UniProt Synonym Protein Names
Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1
Protein Family
UniProt Gene Name
HYAL1  [Similar Products]
UniProt Synonym Gene Names
LUCA1; Hyal-1; LuCa-1  [Similar Products]
UniProt Entry Name
HYAL1_HUMAN
NCBI Summary for HYAL1
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for HYAL1
HYAL1: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9); also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. Belongs to the glycosyl hydrolase 56 family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Glycan Metabolism - glycosaminoglycan degradation; Secreted, signal peptide; Hydrolase; EC 3.2.1.35

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cytoplasm; cytoplasmic vesicle; extracellular space; lysosomal lumen; lysosome

Molecular Function: hyaluronan synthase activity; hyalurononglucosaminidase activity; transcription factor binding; viral receptor activity

Biological Process: carbohydrate metabolic process; cartilage development; chondroitin sulfate catabolic process; chondroitin sulfate metabolic process; glycosaminoglycan metabolic process; hyaluronan biosynthetic process; hyaluronan catabolic process; hyaluronan metabolic process; inflammatory response; negative regulation of cell growth; positive regulation of angiogenesis; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of epithelial cell proliferation; positive regulation of growth; response to antibiotic; response to reactive oxygen species; response to virus

Disease: Mucopolysaccharidosis, Type Ix
Product References and Citations for HYAL1 recombinant protein
Purification, cloning, and expression of human plasma hyaluronidase.Frost G.I., Csoka A.B., Wong T., Stern R.Biochem. Biophys. Res. Commun. 236:10-15(1997)
Regulation of hyaluronidase activity by alternative mRNA splicing.Lokeshwar V.B., Schroeder G.L., Carey R.I., Soloway M.S., Iida N.J. Biol. Chem. 277:33654-33663(2002)
Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis.Chao K.L., Muthukumar L., Herzberg O.Biochemistry 46:6911-6920(2007)
Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX.Triggs-Raine B., Salo T.J., Zhang H., Wicklow B.A., Natowicz M.R.Proc. Natl. Acad. Sci. U.S.A. 96:6296-6300(1999)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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