NP_001157949.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
110,842 Da
NCBI Official Full Name
interferon-induced helicase C domain-containing protein 1 isoform 2
NCBI Official Synonym Full Names
interferon induced with helicase C domain 1
NCBI Official Synonym Symbols
Hlcd; MDA5; RLR-2; Helicard; 9130009C22Rik [Similar Products]
NCBI Protein Information
interferon-induced helicase C domain-containing protein 1
UniProt Protein Name
Interferon-induced helicase C domain-containing protein 1
UniProt Synonym Protein Names
Helicase with 2 CARD domains; Helicard; Interferon induced with helicase C domain protein 1; Melanoma differentiation-associated protein 5; MDA-5; RIG-I-like receptor 2; RLR-2
UniProt Synonym Gene Names
UniProt Entry Name
IFIH1_MOUSE
UniProt Comments for IFIH1
IFIH1: Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O- methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. Monomer in the absence of ligands and homodimerizes in the presence of dsRNA ligands. Can assemble into helical or linear polymeric filaments on long dsRNA. Interacts with MAVS/IPS1. Interacts with V protein of Simian virus 5, Human parainfluenza virus 2, Mumps virus, Sendai virus and Hendra virus. Binding to paramyxoviruses V proteins prevents IFN-beta induction, and the further establishment of an antiviral state. Interacts with PCBP2. Interacts with NLRC5. Interacts with PIAS2-beta. Interacts with DDX60. By interferon (IFN) and TNF. Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung. Belongs to the helicase family. RLR subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Helicase; Apoptosis; EC 3.6.4.13
Cellular Component: cytoplasm; nucleus
Molecular Function: ribonucleoprotein binding; protein binding; single-stranded RNA binding; hydrolase activity, acting on acid anhydrides; DNA binding; hydrolase activity; zinc ion binding; RNA binding; metal ion binding; double-stranded RNA binding; nucleotide binding; helicase activity; ATP binding
Biological Process: regulation of apoptosis; protein sumoylation; immune system process; response to virus; positive regulation of interferon-beta production; innate immune response; defense response to virus; positive regulation of interferon-alpha production
Research Articles on IFIH1
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Products associated with IFIH1 sirna
Pathways associated with IFIH1 sirna
Diseases associated with IFIH1 sirna
Organs/Tissues associated with IFIH1 sirna
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