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IFIT3 cdna clone

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Catalog # MBS1267508
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
IFIT3 cdna clone
Product Name

IFIT3, cDNA Clone

Popular Item
Full Product Name

IFIT3 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgagtgagg tcaccaagaa ttccctggag aaaatccttc cacagctgaa atgccatttc acctggaact tattcaagga agacagtgtc tcaagggatc tagaagatag agtgtgtaac cagattgaat ttttaaacac tgagttcaaa gctacaatgt acaacttgtt ggcctacata aaacacctag atggtaacaa cgaggcagcc ctggaatgct tacggcaagc tgaagagtta atccagcaag aacatgctga ccaagcagaa atcagaagtc tagtcacttg gggaaactac gcctgggtct actatcactt gggcagactc tcagatgctc agatttatgt agataaggtg aaacaaacct gcaagaaatt ttcaaatcca tacagtattg agtattctga acttgactgt gaggaagggt ggacacaact gaagtgtgga agaaatgaaa gggcgaaggt gtgttttgag aaggctctgg aagaaaagcc caacaaccca gaattctcct ctggactggc aattgcgatg taccatctgg ataatcaccc agagaaacag ttctctactg atgttttgaa gcaggccatt gagctgagtc ctgataacca atacgtcaag gttctcttgg gcctgaaact gcagaagatg aataaagaag ctgaaggaga gcagtttgtt gaagaagcct tggaaaagtc tccttgccaa acagatgtcc tccgcagtgc agccaaattt tacagaagaa aaggtgacct agacaaagct attgaactgt ttcaacgggt gttggaatcc acaccaaaca atggctacct ctatcaccag attgggtgct gctacaaggc aaaagtaaga caaatgcaga atacaggaga atctgaagct agtggaaata aagagatgat tgaagcacta aagcaatatg ctatggacta ttcgaataaa gctcttgaga agggactgaa tcctctgaat gcatactccg atctcgctga gttcctggag acggaatgtt atcagacacc attcaataag gaagtccctg atgctgaaaa gcaacaatcc catcagcgct actgcaacct tcagaaatat aatgggaagt ctgaagacac tgctgtgcaa catggtttag agggtttgtc cataagcaaa aaatcaactg acaaggaaga gatcaaagac caaccacaga atgtatctga aaatctgctt ccacaaaatg caccaaatta ttggtatctt caaggattaa ttcataagca gaatggagat ctgctgcaag cagccaaatg ttatgagaag gaactgggcc gcctgctaag ggatgcccct tcaggcatag gcagtatttt cctgtcagca tctgagcttg aggatggtag tgaggaaatg ggccagggcg cagtcagctc cagtcccaga gagctcctct ctaactcaga gcaactgaac tga
OMIM
604650
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of IFIT3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for IFIT3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,985 Da
NCBI Official Full Name
Homo sapiens interferon-induced protein with tetratricopeptide repeats 3, mRNA
NCBI Official Synonym Full Names
interferon induced protein with tetratricopeptide repeats 3
NCBI Official Symbol
IFIT3  [Similar Products]
NCBI Official Synonym Symbols
P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; cig41; CIG-49; GARG-49
  [Similar Products]
NCBI Protein Information
interferon-induced protein with tetratricopeptide repeats 3
UniProt Protein Name
Interferon-induced protein with tetratricopeptide repeats 3
UniProt Synonym Protein Names
CIG49; ISG-60; Interferon-induced 60 kDa protein; IFI-60K; Interferon-induced protein with tetratricopeptide repeats 4; IFIT-4; Retinoic acid-induced gene G protein; P60; RIG-G
UniProt Gene Name
IFIT3  [Similar Products]
UniProt Synonym Gene Names
CIG-49; IFI60; IFIT4; ISG60; IFIT-3; IFI-60K; IFIT-4; P60; RIG-G  [Similar Products]
UniProt Entry Name
IFIT3_HUMAN
UniProt Comments for IFIT3
IFIT3: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. Belongs to the IFIT family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: cytoplasm; cytosol; mitochondrion

Molecular Function: identical protein binding; protein binding; RNA binding

Biological Process: defense response to virus; negative regulation of apoptosis; negative regulation of cell proliferation; response to virus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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