NP_066362.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,632 Da
NCBI Official Full Name
interferon-induced transmembrane protein 3
NCBI Official Synonym Full Names
interferon induced transmembrane protein 3
NCBI Protein Information
interferon-induced transmembrane protein 3
UniProt Protein Name
Interferon-induced transmembrane protein 3
UniProt Synonym Protein Names
Dispanin subfamily A member 2b; DSPA2b; Interferon-inducible protein 1-8U
UniProt Synonym Gene Names
UniProt Entry Name
IFM3_HUMAN
NCBI Summary for IFITM3
The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]
UniProt Comments for IFITM3
IFITM3: IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. Interacts with SPP1; the interaction reduces OPN expression. By IFN-alpha and IFNG/IFN-gamma. Belongs to the CD225/Dispanin family.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: lysosomal membrane; late endosome membrane; integral to membrane; plasma membrane
Molecular Function: protein binding
Biological Process: negative regulation of viral transcription; negative regulation of viral genome replication; negative regulation of virion penetration into host cell; response to virus; cytokine and chemokine mediated signaling pathway; immune response; defense response to virus
Disease: Influenza, Severe, Susceptibility To
Research Articles on IFITM3
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Products associated with IFITM3 clia kit
Pathways associated with IFITM3 clia kit
Diseases associated with IFITM3 clia kit
Organs/Tissues associated with IFITM3 clia kit
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