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IFN-lambda1 recombinant protein

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Catalog # MBS696050
Unit / Price
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  0.005 mg  /  $125 +1 FREE 8GB USB
  0.02 mg  /  $195 +1 FREE 8GB USB
  0.1 mg  /  $505 +1 FREE 8GB USB
  0.5 mg  /  $1,410 +1 FREE 8GB USB
  1 mg  /  $2,320 +2 FREE 8GB USB
IFN-lambda1 recombinant protein
Product Name

IFN-lambda1, Recombinant Protein

Popular Item
Full Product Name

Human IFN-lambda1

Product Synonym Names
Recombinant Human IFN-lambda1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
PTSKPTTTG KGCHIGRFK SLSPQELAS FKKARDALE ESLKLKNWS CSSPVFPGN WDLRLLQVR ERPVALEAE LALTLKVLE AAAGPALED VLDQPLHTL HHILSQLQA CIQPQPTAG PRPRGRLHH WLHRLQEAP KKESAGCLE ASVTFNLFR LLTRDLKYV ADGNLCLRT STHPEST
OMIM
607403
3D Structure
ModBase 3D Structure for Q8IU54
Host
E Coli
Species Reactivity
Species Reactivity: Human
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Form/Format
Sterile filtered through a 0.2 micron filter. Lyophilized from 10mM Sodium Phoshpate, pH7.5
Species
Human
Biological Activity
Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml.
Authenticity
Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin level
<0.1 ng/ug of protein (<1EU/ug)
Protein Content
Verified by UV Spectroscopy and/or SDS-PAGE gel
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C
Preparation and Storage
Store at -20°C
Other Notes
Small volumes of IFN-lambda1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IFN-lambda1 recombinant protein
IFN lambda-1, -2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and Interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-lambdaR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons. (Kotenko, SV. et al. Nat Immunology 2003 [1] p. 69-77). Recombinant human IFN-lambda 1 is a 19.8 kDa protein containing 178 amino acid residues.
NCBI/Uniprot data below describe general gene information for IFN-lambda1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,898 Da
NCBI Official Full Name
Interferon lambda-1
NCBI Official Synonym Full Names
interferon, lambda 1
NCBI Official Symbol
IFNL1  [Similar Products]
NCBI Official Synonym Symbols
IL29; IL-29
  [Similar Products]
NCBI Protein Information
interferon lambda-1; IFN-lambda-1; interleukin-29; cytokine Zcyto21; interferon-lambda-1; interleukin 29 (interferon, lambda 1)
UniProt Protein Name
Interferon lambda-1
UniProt Synonym Protein Names
Cytokine Zcyto21; Interleukin-29; IL-29
UniProt Gene Name
IFNL1  [Similar Products]
UniProt Synonym Gene Names
IL29; ZCYTO21; IFN-lambda-1; IL-29  [Similar Products]
UniProt Entry Name
IFNL1_HUMAN
NCBI Summary for IFN-lambda1
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
UniProt Comments for IFN-lambda1
IL29: Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.

Protein type: Secreted, signal peptide; Cytokine; Cell cycle regulation; Secreted

Chromosomal Location of Human Ortholog: 19q13.13

Cellular Component: extracellular space; extracellular region; interleukin-28 receptor complex

Molecular Function: cytokine activity; interleukin-28 receptor binding; receptor binding

Biological Process: positive regulation of immune response; positive regulation of transcription, DNA-dependent; positive regulation of JAK-STAT cascade; JAK-STAT cascade; negative regulation of T cell differentiation; negative regulation of cell proliferation; negative regulation of interleukin-13 production; positive regulation of interferon-gamma production; positive regulation of tyrosine phosphorylation of STAT protein; negative regulation of T-helper 2 type immune response; negative regulation of interleukin-5 production; positive regulation of MHC class I biosynthetic process; negative regulation of transcription, DNA-dependent; negative regulation of memory T cell differentiation; defense response to virus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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