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IFNGR1 blocking peptide

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Catalog # MBS8243970
Unit / Price
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  1 mg  /  $160 +1 FREE 8GB USB
  5 mg  /  $305 +1 FREE 8GB USB
IFNGR1 blocking peptide
Product Name

IFNGR1, Blocking Peptide

Popular Item
Full Product Name

IFNGR1 Blocking Peptide

Product Synonym Names
Interferon gamma receptor 1; IFN-gamma receptor 1; IFN-gamma-R1; CDw119; CD119
Antibody/Peptide Pairs
IFNGR1 peptide (MBS8243970) is used for blocking the activity of IFNGR1 antibody (MBS8241622)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
107470
3D Structure
ModBase 3D Structure for P15260
Host
Synthetic
Species Reactivity
Human, Rat
Purity/Purification
>85%
Form/Format
Lyophilized Powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of IFNGR1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IFNGR1 blocking peptide
The peptide is used to block Anti-IFNGR1 Antibody reactivity.
Applications Tested/Suitable for IFNGR1 blocking peptide
Blocking (BL)
Application Notes for IFNGR1 blocking peptide
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
NCBI/Uniprot data below describe general gene information for IFNGR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,542 Da
NCBI Official Full Name
Interferon gamma receptor 1
NCBI Official Synonym Full Names
interferon gamma receptor 1
NCBI Official Symbol
IFNGR1  [Similar Products]
NCBI Official Synonym Symbols
CD119; IFNGR; IMD27A; IMD27B
  [Similar Products]
NCBI Protein Information
interferon gamma receptor 1
UniProt Protein Name
Interferon gamma receptor 1
UniProt Synonym Protein Names
CDw119; CD_antigen: CD119
Protein Family
UniProt Gene Name
IFNGR1  [Similar Products]
UniProt Synonym Gene Names
IFN-gamma receptor 1; IFN-gamma-R1  [Similar Products]
UniProt Entry Name
INGR1_HUMAN
NCBI Summary for IFNGR1
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]
UniProt Comments for IFNGR1
IFNGR1: Receptor for interferon gamma. Two receptors bind one interferon gamma dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type II cytokine receptor family.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: interferon-gamma receptor activity; interleukin-20 binding; protein binding

Biological Process: cytokine and chemokine mediated signaling pathway; response to virus; signal transduction

Disease: Helicobacter Pylori Infection, Susceptibility To; Hepatitis B Virus, Susceptibility To; Immunodeficiency 27a; Immunodeficiency 27b; Mycobacterium Tuberculosis, Susceptibility To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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