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IGF1 recombinant protein :: Insulin-Like Growth Factor I (rHuIGF-I) Recombinant Protein

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Catalog # MBS197011
Unit / Price
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  0.02 mg  /  $195 +1 FREE 8GB USB
  0.1 mg  /  $280 +1 FREE 8GB USB
  1 mg  /  $435 +1 FREE 8GB USB
IGF1 recombinant protein
Product Name

Insulin-Like Growth Factor I (rHuIGF-I) (IGF1), Recombinant Protein

Full Product Name

Recombinant Human Insulin-Like Growth Factor I(rHuIGF-1)

Product Synonym Names
Recombinant Human Insulin-Like Growth Factor I (rHuIGF-I)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 12; NC_000012.11 (102789645..102874378, complement). Location: 12q23.2
OMIM
147440. gene. :: 608747. phenotype.
3D Structure
ModBase 3D Structure for P01343
Host
E Coli
Specificity
Recombinant Human Insulin-Like Growth Factor I (rHuIGF-I)
Purity/Purification
Greater than 98% by RP-HPLC, anion-exchange chromatography; reducing and non-reducing SDS-PAGE, silver stain.
Purification: Chromatographic
Form/Format
Sterile filtered, lyophilized.
Dimers/Aggregates
<1% by SDSPAGE
Biological Activity
Fully biologically active compared to reference standards. Specific activity is 1 x 10^6 IU/mg. Biological activity at 0.2-20 ng/ml.
Endotoxin Level
<0.1 ng/ug
Protein Content
Determined spectrophotometrically at 280nm (0.502 ext. coeff), and by RP-HPLC analysis against a calibrated standard.
Solubility
Reconstitute the lyophilized product in sterile water not less than 100 ug/ml. Product was dialyzed against 50mM acetate prior to lyophilization.
Stabilizer
None
Preservatives
None
Preparation and Storage
Lyophilized product is stable at room temperature for 3 weeks. Store lyophilized product desiccated at -20 degree C. Upon reconstitution, store at 4 degree C for 2-7 days or aliquot and store at -20 degree C. For long-term storage add either HSA or BSA to 0.1%. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of IGF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IGF1 recombinant protein
Recombinant Human IGF-1 produced in E. coli is a single, non-glycosylated polypeptide chain containing 70 amino acids with a molecular mass of 7,655 daltons. This product has full biological activity.
Product Categories/Family for IGF1 recombinant protein
NCBI/Uniprot data below describe general gene information for IGF1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
17,026 Da[Similar Products]
NCBI Official Full Name
insulin-like growth factor I
NCBI Official Synonym Full Names
insulin-like growth factor 1 (somatomedin C)
NCBI Official Symbol
NCBI Official Synonym Symbols
IGFI; IGF-I; IGF1A
  [Similar Products]
NCBI Protein Information
insulin-like growth factor 1; MGF; IGF-IA; IGF-IB; somatomedin-C; OTTHUMP00000195080; OTTHUMP00000195081; OTTHUMP00000195082; OTTHUMP00000195083; OTTHUMP00000195084; mechano growth factor; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB
UniProt Protein Name
Insulin-like growth factor 1 (Somatomedin C)
UniProt Synonym Protein Names
Somatomedin-C; Mechano growth factor; MGF
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
Q5U743_HUMAN
NCBI Summary for IGF1
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
UniProt Comments for IGF1
IGF1: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency). IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. Belongs to the insulin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: insulin-like growth factor binding protein complex; extracellular space; extracellular region; plasma membrane

Molecular Function: integrin binding; insulin-like growth factor receptor binding; protein binding; growth factor activity; hormone activity; insulin receptor binding

Biological Process: muscle development; positive regulation of transcription, DNA-dependent; chondroitin sulfate proteoglycan biosynthetic process; glycolate metabolic process; exocrine pancreas development; water homeostasis; positive regulation of glucose import; positive regulation of fibroblast proliferation; proteoglycan biosynthetic process; inner ear development; positive regulation of DNA binding; muscle hypertrophy; platelet activation; positive regulation of protein import into nucleus, translocation; positive regulation of mitosis; regulation of establishment and/or maintenance of cell polarity; positive regulation of phosphoinositide 3-kinase cascade; cell activation; positive regulation of peptidyl-tyrosine phosphorylation; insulin-like growth factor receptor signaling pathway; branching morphogenesis of a tube; regulation of gene expression; response to heat; positive regulation of transcription from RNA polymerase II promoter; alveolus development; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of smooth muscle cell proliferation; myoblast proliferation; positive regulation of glycogen biosynthetic process; signal transduction; positive regulation of activated T cell proliferation; positive regulation of smooth muscle cell migration; negative regulation of cell proliferation; platelet degranulation; glial cell differentiation; positive regulation of MAPKKK cascade; mammary gland development; positive regulation of cell proliferation; DNA replication; skeletal development; positive regulation of granule cell precursor proliferation; phosphoinositide-mediated signaling; multicellular organism growth; regulation of multicellular organism growth; myotube cell development; satellite cell compartment self-renewal involved in skeletal muscle regeneration; myoblast differentiation; positive regulation of protein kinase B signaling cascade; positive regulation of osteoblast differentiation; cell proliferation; cellular protein metabolic process; positive regulation of tyrosine phosphorylation of Stat5 protein; Ras protein signal transduction; positive regulation of glycolysis; blood vessel remodeling; positive regulation of Ras protein signal transduction; cell motility; blood coagulation; positive regulation of DNA replication

Disease: Insulin-like Growth Factor I Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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