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IGF1R elisa kit

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Catalog # MBS9501480
Unit / Price
  2x96 Wells  /  $535 +1 FREE 8GB USB
IGF1R elisa kit
Product Name

IGF1R, ELISA Kit

Popular Item
Also Known As

Phospho-IGF1R (Tyr1165/Tyr1166) Colorimetric Cell-Based ELISA Kit

Product Synonym Names
CD221; IGF1R; Insulin-like growth factor I receptor precursor; kinase IGF1R
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
Sequence Length
1367
OMIM
X04434 mRNA
3D Structure
ModBase 3D Structure for P08069
Species Reactivity
Form/Format
Two 96-Well Plates
Samples
Researchers plate their cell line of choice
Assay Type
Phospho Cell-Based ELISA
Sensitivity
>=5000 cells/well
Reactivity Note
Human: Y1165+Y1166/Y1189+Y1190, Mouse: Y1167+Y1168/Y1179+Y1180, Rat: Y1166+Y1167/Y1190+Y1191
Detection Method
Colorimetric 450 nm
Preparation and Storage
Store at 4 degree C.
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of IGF1R elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forIGF1Rpurchase
MBS9501480 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the IGF1R, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing IGF1R. The ELISA analytical biochemical technique of the MBS9501480 kit is based on IGF1R antibody-IGF1R antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IGF1R antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IGF1R. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Product Categories/Family for IGF1R elisa kit
Sample Manual Insert of MBS9501480. Click to request current manual
NCBI/Uniprot data below describe general gene information for IGF1R. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
154793
NCBI Official Full Name
insulin-like growth factor 1 receptor isoform 1
NCBI Official Synonym Full Names
insulin like growth factor 1 receptor
NCBI Official Symbol
IGF1R  [Similar Products]
NCBI Official Synonym Symbols
IGFR; CD221; IGFIR; JTK13
  [Similar Products]
NCBI Protein Information
insulin-like growth factor 1 receptor
UniProt Protein Name
Insulin-like growth factor 1 receptor
UniProt Synonym Protein Names
Insulin-like growth factor I receptor; IGF-I receptor
UniProt Gene Name
IGF1R  [Similar Products]
UniProt Synonym Gene Names
IGF-I receptor  [Similar Products]
NCBI Summary for IGF1R
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
UniProt Comments for IGF1R
IGF1R: a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541.

Protein type: EC 2.7.10.1; InsR family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: integral component of plasma membrane; intracellular membrane-bound organelle; membrane; plasma membrane; receptor complex

Molecular Function: ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor-activated receptor activity; phosphoinositide 3-kinase binding; protein binding; protein tyrosine kinase activity

Biological Process: cellular response to amyloid-beta; immune response; inactivation of MAPKK activity; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; negative regulation of apoptosis; peptidyl-tyrosine autophosphorylation; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of protein complex disassembly; protein autophosphorylation; protein tetramerization; regulation of JNK cascade; signal transduction

Disease: Insulin-like Growth Factor I, Resistance To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with IGF1R elisa kit
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