• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-IGFBP-3 antibody :: anti-Human, Mouse IGFBP-3 Antibody

Scan QR to view Datasheet
Catalog # MBS859480
Unit / Price
Scan QR to view Datasheet
  0.1 mg  /  $215 +1 FREE 8GB USB
Product Name

IGFBP-3, Antibody

Popular Item
Full Product Name

IGFBP-3 (Phospho-Ser183) Antibody

Product Synonym Names
IBP-3; IBP3; IGF-binding protein 3; IGFBP3; Insulin-like growth factor binding protein 3 precursor
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
146732
3D Structure
ModBase 3D Structure for P17936
Species Reactivity
Human, Mouse
Specificity
IGFBP-3 (Phospho-Ser183) antibody detects endogenous levels of IGFBP-3 only when phosphorylated at serine 183.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human IGFBP-3 around the phosphorylation site of serine 183 (K-D-SP-Q-R).
All Sites
Human: Ser183
Mouse: Ser183
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-IGFBP-3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-IGFBP-3 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-IGFBP-3 antibody
IHC: 1:50-1:100
ELISA: 1:1000

Testing Data of anti-IGFBP-3 antibody
P-peptide-+
anti-IGFBP-3 antibody Testing Data image
Immunohistochemistry (IHC) of anti-IGFBP-3 antibody
Immunohistochemistry analysis of paraffin-embedded human brain tissue using IGFBP-3 (Phospho-Ser183) antibody. IGFBP-3 (Phospho-Ser183) antibody reacts with epitope-specific phosphopeptide and corresponding non-phosphopeptide. The absorbance readings at 450 nM are shown in the ELISA figure.
anti-IGFBP-3 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for IGFBP-3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,223 Da
NCBI Official Full Name
insulin-like growth factor-binding protein 3 isoform b
NCBI Official Synonym Full Names
insulin like growth factor binding protein 3
NCBI Official Symbol
IGFBP3  [Similar Products]
NCBI Official Synonym Symbols
IBP3; BP-53
  [Similar Products]
NCBI Protein Information
insulin-like growth factor-binding protein 3
UniProt Protein Name
Insulin-like growth factor-binding protein 3
UniProt Gene Name
IGFBP3  [Similar Products]
UniProt Synonym Gene Names
IBP3; IBP-3; IGF-binding protein 3; IGFBP-3  [Similar Products]
NCBI Summary for IGFBP-3
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for IGFBP-3
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Product References and Citations for anti-IGFBP-3 antibody
C. Schmid, Am J Physiol Endocrinol Metab, Aug 1994; 267: E226-E233. Hanh Le, Am J Physiol Endocrinol Metab, May 2006; 290: E952-E960. C. A. Gibson, J Anim Sci, Jun 1999; 77: 1547-1557.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000