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anti-IGFBP2 antibody :: Mouse anti-Human IGFBP2 Antibody

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Catalog # MBS850197
Unit / Price
  0.1 mg  /  $290 +1 FREE 8GB USB
Product Name

IGFBP2, Antibody

Full Product Name

Antibody to IGFBP2 Antibody

Product Synonym Names
IBP2; IGF-BP53
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
146731
3D Structure
ModBase 3D Structure for P18065
Isotype
IgG1
Clone Number
1F6F6
Host
Mouse
Species Reactivity
Human
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Immunogen
Purified recombinant fragment of protein IGFBP2 (aa180-328) expressed in E. Coli.
Preparation and Storage
Store at 4 degree C, for long term storage, store at-20 degree C
Other Notes
Small volumes of anti-IGFBP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IGFBP2 antibody
IGFBP2. insulin-like growth factor binding protein 2. IGFBP2 is a member of the ISGBP family which bind various IGFs. IGFBP2 is overexpressed in a wide spectrum of other cancers, including glioma, prostate cancer, synovial sarcoma, neuroblastoma, colon cancer, adrenocortical cancer, lung cancer, Wilms' tumor, and hepatoblastoma. The overexpression of IGFBP2 also correlates with the aggressiveness of some tumors. IGFBP2 activates the expression of matrix metalloprotease 2, which contributes to cell invasiveness.
Applications Tested/Suitable for anti-IGFBP2 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-IGFBP2 antibody
WB: 1:500-1:2000
IHC: 1:200-1:1000
ELISA: 1:10000

Testing Data of anti-IGFBP2 antibody
Figure 1. Western blot analysis using IGFBP2 mouse mAb against truncated IGFBP2-His recombinant protein (1) and truncated IGFBP2 (aa40-328)-hIgGFc transfected CHO-K1 cell lysate (2).
anti-IGFBP2 antibody Testing Data image
Testing Data #2 of anti-IGFBP2 antibody
Figure 2. Immunohistochemical analysis of paraffin-embedded human lung cancer (A), recturn(B), prostate (C), colon cancer (D) showing cytoplasmic localization using IGFBP2 mouse mAb with DAB staining.
anti-IGFBP2 antibody Testing Data #2 image
NCBI/Uniprot data below describe general gene information for IGFBP2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,814 Da
NCBI Official Full Name
insulin-like growth factor-binding protein 2 isoform a
NCBI Official Synonym Full Names
insulin like growth factor binding protein 2
NCBI Official Symbol
IGFBP2  [Similar Products]
NCBI Official Synonym Symbols
IBP2; IGF-BP53
  [Similar Products]
NCBI Protein Information
insulin-like growth factor-binding protein 2
UniProt Protein Name
Insulin-like growth factor-binding protein 2
UniProt Gene Name
IGFBP2  [Similar Products]
UniProt Synonym Gene Names
BP2; IBP2; IBP-2; IGF-binding protein 2; IGFBP-2  [Similar Products]
NCBI Summary for IGFBP2
The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]
UniProt Comments for IGFBP2
Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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