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IGFBP7 recombinant protein :: Insulin Like Growth Factor Binding Protein-7 Recombinant Protein

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Catalog # MBS146624
Unit / Price
  0.005 mg  /  $140 +1 FREE 8GB USB
  0.025 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $2,665 +3 FREE 8GB USB
IGFBP7 recombinant protein
Product Name

Insulin Like Growth Factor Binding Protein-7 (IGFBP7), Recombinant Protein

Popular Item
Also Known As

Recombinant Human Insulin Like Growth Factor Binding Protein-7

Product Synonym Names
IGFBP7 Human; Insulin-Like Growth Factor Binding Protein-7 Human Recombinant; Insulin-like growth factor-binding protein 7; IBP-7; IGF-binding protein 7; IGFBP-7; IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor; TAF; IGFBP7; MAC25; PSF; AGM; FSTL2; RAMSVPS; IGFBP-7v; IGFBPRP1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
SSSDTCGPCE PASCPPLPPL GCLLGETRDA CGCCPMCARG EGEPCGGGGA GRGYCAPGME CVKSRKRRKG KAGAAAGGPG VSGVCVCKSR YPVCGSDGTT YPSGCQLRAA SQRAESRGEK AITQVSKGTC EQGPSIVTPP KDIWNVTGAQ VYLSCEVIGI PTPVLIWNKV KRGHYGVQRT ELLPGDRDNL AIQTRGGPEK HEVTGWVLVS PLSKEDAGEY ECHASNSQGQ ASASAKITVV DALHEIPVKK GEGAEL
OMIM
602867
3D Structure
ModBase 3D Structure for Q16270
Purity/Purification
Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Form/Format
The IGFBP7 was lyophilized from a 0.2 um filtered concentrated solution in 20mM Tris-HCl, pH 8.5 and 150mM NaCl.
Sterile Filtered White lyophilized (freeze-dried) powder.
Source
E.coli
Solubility
It is recommended to reconstitute the lyophilzed IGFBP-7 in sterile 20mM AcOH (acetic Acid) not less than 100ug/ml, which can then be further diluted to otehr aqueous solutions.
Preparation and Storage
Lyophilized IGFBP7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGFBP-7 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1 HSA or BSA).
Please prevent freeze-thaw cycles.
Other Notes
Small volumes of IGFBP7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IGFBP7 recombinant protein
Description: Recombinant Human IGFBP7 produced in E Coli cells is a non-glycosylated, homodimeric protein containing 2 x 256 amino acid chains and having a molecular mass of 26.4kDa. The IGFBP-7 is purified by proprietary chromatographic techniques.

Introduction: Insulin-like Growth Factor-Binding Protein 7 (IGFBP7) is a member of the IGFBP family. IGFBP family members are all cysteine rich proteins with conserved cysteine and have an IGFBP domain, a Kazal-like domain and an Ig-like C2-type domain. IGFBP7 is expressed in a broad range of normal human tissues and it mostly shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. IGFBP7 has a role in skeletal myogenesis by binding to IGF in a manner which inhibits IGF induced differentiation of skeletal myoblasts, without disturbing IGF induced proliferation. Moreover, IGFBP7 suppresses growth and colony formation of prostate and breast cancer cell lines via an IGF independent mechanism, which triggers a delay in the G1 phase of the cell cycle, and increased apoptosis.
NCBI/Uniprot data below describe general gene information for IGFBP7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
insulin-like growth factor-binding protein 7 isoform 2
NCBI Official Synonym Full Names
insulin-like growth factor binding protein 7
NCBI Official Symbol
IGFBP7  [Similar Products]
NCBI Official Synonym Symbols
AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1
  [Similar Products]
NCBI Protein Information
insulin-like growth factor-binding protein 7; IGF-binding protein 7; IGFBP-rP1; PGI2-stimulating factor; angiomodulin; prostacyclin-stimulating factor; tumor-derived adhesion factor
UniProt Protein Name
Insulin-like growth factor-binding protein 7
UniProt Synonym Protein Names
IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor; TAF
UniProt Gene Name
IGFBP7  [Similar Products]
UniProt Synonym Gene Names
MAC25; PSF; IBP-7; IGF-binding protein 7; IGFBP-7; TAF  [Similar Products]
UniProt Entry Name
IBP7_HUMAN
NCBI Summary for IGFBP7
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]
UniProt Comments for IGFBP7
IGFBP7: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS). RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.

Protein type: Secreted; Cell cycle regulation; Cell adhesion; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: insulin-like growth factor binding; protein binding

Biological Process: negative regulation of cell proliferation; response to cortisol stimulus; response to retinoic acid; response to heat; regulation of steroid biosynthetic process; regulation of cell growth; cell adhesion; inner ear development; embryo implantation; cellular response to hormone stimulus

Disease: Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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