NP_064455.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,963 Da
NCBI Official Full Name
immunoglobulin lambda-like polypeptide 1 isoform a
NCBI Official Synonym Full Names
immunoglobulin lambda-like polypeptide 1
NCBI Official Synonym Symbols
IGO; 14.1; AGM2; IGL1; IGL5; IGLL; IGVPB; CD179b; VPREB2; IGLJ14.1 [Similar Products]
NCBI Protein Information
immunoglobulin lambda-like polypeptide 1; lambda5; ig lambda-5; CD179b antigen; CD179 antigen-like family member B; Pre-B lymphocyte-specific protein-2; immunoglobulin-related 14.1 protein; immunoglobulin-related protein 14.1; immunoglobulin omega polypeptide chain
UniProt Protein Name
Immunoglobulin lambda-like polypeptide 1
UniProt Synonym Protein Names
CD179 antigen-like family member B; Ig lambda-5; Immunoglobulin omega polypeptide; Immunoglobulin-related protein 14.1; CD_antigen: CD179b
UniProt Synonym Gene Names
UniProt Entry Name
IGLL1_HUMAN
NCBI Summary for IGLL1
The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for IGLL1
IGLL1: Critical for B-cell development. Defects in IGLL1 are the cause of agammaglobulinemia type 2 (AGM2). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component: membrane
Biological Process: immune response
Disease: Agammaglobulinemia 2, Autosomal Recessive
Research Articles on IGLL1
Precautions
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Pathways associated with IGLL1 elisa kit
Diseases associated with IGLL1 elisa kit
Organs/Tissues associated with IGLL1 elisa kit
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