NP_000566.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,607 Da
NCBI Official Full Name
interleukin-1 alpha proprotein
NCBI Official Synonym Full Names
interleukin 1, alpha
NCBI Protein Information
interleukin-1 alpha; IL-1 alpha; hematopoietin-1; preinterleukin 1 alpha; pro-interleukin-1-alpha
UniProt Protein Name
Interleukin-1 alpha
UniProt Synonym Protein Names
Hematopoietin-1
UniProt Synonym Gene Names
UniProt Entry Name
IL1A_HUMAN
NCBI Summary for IL-1
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
UniProt Comments for IL-1
IL1A: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Belongs to the IL-1 family.
Protein type: Motility/polarity/chemotaxis; Cytokine
Chromosomal Location of Human Ortholog: 2q14
Cellular Component: extracellular space; extracellular region; cytosol
Molecular Function: protein binding; copper ion binding; interleukin-1 receptor binding; cytokine activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of mitosis; apoptosis; positive regulation of interleukin-2 biosynthetic process; cytokine and chemokine mediated signaling pathway; germ cell programmed cell death; positive regulation of JNK cascade; fever; negative regulation of cell proliferation; cell proliferation; positive regulation of angiogenesis; connective tissue replacement during inflammatory response; response to copper ion; immune response; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; positive regulation of cytokine secretion
Research Articles on IL-1
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Products associated with IL-1 elisa kit
Pathways associated with IL-1 elisa kit
Diseases associated with IL-1 elisa kit
Organs/Tissues associated with IL-1 elisa kit
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