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IL-8 western blot control :: Interleukin-8 (IL-8) Western Blot Control

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Catalog # MBS343082
Unit / Price
  0.01 mg  /  $215 +1 FREE 8GB USB
IL-8 western blot control
Product Name

Interleukin-8 (IL-8), Western Blot Control

Full Product Name

Interleukin-8 (IL-8) (Western Blot Control)

Product Synonym Names
IL-8, CXCL8, Monocyte-derived neutrophil chemotactic factor, MDNCF, T-cell chemotactic factor, Neutrophil-activating protein 1, NAP-1, Protein 3-10C, Granulocyte chemotactic protein 1, GCP-1, Monocyte derived neutrophil activating peptide, MONAP, Emoctakin.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
146930
3D Structure
ModBase 3D Structure for P10145
Purity/Purification
>= 95% (SDS PAGE)
Form/Format
Liquid
Buffer
Buffered 50% glycerol
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of IL-8 western blot control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IL-8 western blot control
Interleukin-8 (IL-8) belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states. Recombinant IL-8 comprises the 77 amino acid fragment (23-99) corresponding to the mature IL-8 protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.
NCBI/Uniprot data below describe general gene information for IL-8. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,098 Da
NCBI Official Full Name
interleukin-8
NCBI Official Synonym Full Names
C-X-C motif chemokine ligand 8
NCBI Official Symbol
CXCL8  [Similar Products]
NCBI Official Synonym Symbols
IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1
  [Similar Products]
NCBI Protein Information
interleukin-8
UniProt Protein Name
Interleukin-8
UniProt Synonym Protein Names
C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1
Protein Family
UniProt Gene Name
CXCL8  [Similar Products]
UniProt Synonym Gene Names
IL8; IL-8; GCP-1; MDNCF; MONAP; NAP-1; LYNAP; NAF  [Similar Products]
UniProt Entry Name
IL8_HUMAN
NCBI Summary for IL-8
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]
UniProt Comments for IL-8
IL8: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. Belongs to the intercrine alpha (chemokine CxC) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q13-q21

Cellular Component: extracellular region

Molecular Function: chemokine activity; interleukin-8 receptor binding; protein binding

Biological Process: angiogenesis; calcium-mediated signaling; cell cycle arrest; cell motility; chemotaxis; embryonic gut development; G-protein coupled receptor protein signaling pathway; immune response; induction of positive chemotaxis; inflammatory response; negative regulation of cell proliferation; negative regulation of G-protein coupled receptor protein signaling pathway; neutrophil activation; neutrophil chemotaxis; positive regulation of angiogenesis; receptor internalization; regulation of cell adhesion; regulation of retroviral genome replication; response to molecule of bacterial origin; signal transduction
Product References and Citations for IL-8 western blot control
Baggiolini, M & Clark-Lewis I (1992) FEBS Letters 307 (1): 97-101.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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