• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

IL1R2 recombinant protein :: IL-1 receptor type II (CD121b) Recombinant Protein

Scan QR to view Datasheet
Catalog # MBS553264
Unit / Price
  0.05 mg  /  $220 +1 FREE 8GB USB
  0.2 mg  /  $655 +1 FREE 8GB USB
  1 mg  /  $2,525 +3 FREE 8GB USB
IL1R2 recombinant protein
Product Name

IL-1 receptor type II (CD121b) (IL1R2), Recombinant Protein

Popular Item
Also Known As

Mouse IL-1 receptor type II Recombinant (CD121b)

Product Synonym Names
Mouse IL-1 receptor type II Recombinant; CD121B; D2S1473; IL-1R1; IL1R2; IL1RB; P80; IL1R2
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
410
3D Structure
ModBase 3D Structure for P27931
Purity/Purification
>97%, as determined by SDS-PAGE and HPLC
Source
Optimized DNA sequence encoding Mouse extracellular domain of mouse IL-1 receptor type II including a C-terminal His tag was expressed in HEK293 cells
Biological Activity
Measured in an ELISA assay . The ability of mouse IL1R2 (10ug/ml) to bind biotinylated human IL1B was determined to be 0.5 ug/ml
Molecular weight
Recombinant mouse IL-1 receptor type II (CD121b) is a protein consisting of 350 amino acid residue subunits, due to glycosylation migrates as an approximately 90 kDa protein on SDS-PAGE.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug(1EU/ug).
Presentation
Recombinant Mouse IL-1 receptor II (CD121b) is lyophilized from 0.2 um filtered PBS solution, pH7.2 , 5% Trehalose,0.01% tween80
Preparation and Storage
Recombinant Mouse IL1R2 can be stored in working aliquots at 2°C- 8°C for one month, or at -20°C to -70°C for twelve months.
Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of IL1R2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IL1R2 recombinant protein
Two distinct IL-lRs have been identified, termed type I and type II. The type I IL-lR is an 80-kDa glycoprotein found predominantly on T cells and fibroblasts, whereas the type II IL-lR is a 60- to 65-kDa molecule that is expressed on activated T cells, B cells, monocytes, and neutrophils. Evidence suggests that the type II IL-lR is not signal- transducing, and its function on the cell surface is unknown. The action of IL-1 is modulated not only by IL-lra but also by the release of a type II soluble IL-iR (sIL-lR). This 47-kDa soluble receptor is present in normal human plasma, serum, and synovial inflammatory exudate and in culture supernatants of activated peripheral blood mononuclear cells and neutrophils. sIL-lR is also released from the human B-cell Burkitt lymphoma cell line Raji, which expresses only type II IL-1R.
Product Categories/Family for IL1R2 recombinant protein
NCBI/Uniprot data below describe general gene information for IL1R2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
Molecular Weight
Recombinant mouse IL-1 receptor type II (CD121b) is a protein consisting of 350 amino acid residue subunits, due to glycosylation migrates as an approximately 90 kDa protein on SDS-PAGE.
NCBI Official Full Name
interleukin-1 receptor type 2
UniProt Protein Name
Interleukin-1 receptor type 2
UniProt Synonym Protein Names
CD121 antigen-like family member B; IL-1 type II receptor; Interleukin-1 receptor beta; IL-1R-beta; Interleukin-1 receptor type II
Protein Family
UniProt Gene Name
Il1r2  [Similar Products]
UniProt Synonym Gene Names
Il-1r2; Il1rb; IL-1R-2; IL-1RT-2; IL-1RT2; IL-1R-beta; mIL-1R2; mIL-1RII; sIL-1R2; sIL-1RII  [Similar Products]
UniProt Entry Name
IL1R2_MOUSE
UniProt Comments for IL1R2
IL-1RB: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Belongs to the interleukin-1 receptor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: membrane; plasma membrane; integral to membrane; extracellular region

Molecular Function: interleukin-1, Type II, blocking receptor activity; interleukin-1 receptor activity

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000