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IL2 protein :: Interleukin-2 Protein

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Catalog # MBS546055
Unit / Price
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  0.01 mg  /  $165 +1 FREE 8GB USB
  0.05 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $605 +1 FREE 8GB USB
IL2 protein
Product Name

Interleukin-2 (IL2), Protein

Popular Item
Full Product Name

Recombinant Human Interleukin-2 (rHu IL-2)

Product Synonym Names
Interleukin-2; human IL-2; Human Interleukin-2
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MAPSTSSSST KK TQLQLEHLLL DLQMILGIN NYJNOJKTRM LTFKFYMPPK K ATELKHLQCL EEELKPLEEV LNAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFCQSII STLT
Chromosome Location
Chromosome: 4; NC_000004.11 (123372625..123377650, complement). Location: 4q26-q27
OMIM
147680
3D Structure
ModBase 3D Structure for P60568
Host
Escherichia Coli
Purity/Purification
>97% by SDS-PAGE and HPLC analyses
Form/Format
Lyophilized from a 0.2mm filtered concentrated (1mg/ml) solution in PBS, pH 7.5.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder
Molecular Weight Information
Approximately 15 kDa, a single non-glycosylated polypeptide chain containing 134 amino acids
Preparation and Storage
This lyophilized preparation is stable at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of IL2 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IL2 protein
Interleukin 2 is a protein that has a variety of immunologic functions, the most notable being the ability of IL-2 to promote the proliferation and maturation of activated T cells. A comparison of the amino acid sequences of human and murine IL-2 shows and approximately 60% sequence similarity, and human sequence IL-2 has been found to be active on murine cell lines. Some of the biological activities attributed to IL-2 include.
Induction of secretion of interferon-y and tumor necrosis factors a and beta from peripheral blood mononuclear cells.
*Stimulation of the rate of synthesis of c-myc RNA and transferrin receptor.
*Activation of neutrophils.
*Stimulation of proliferation and maturation of activated helper T cells.
*Stimulation of proliferation of activated and natural killer cells and tumor infiltrating lymphocytes as well as enhancement of the ability of these cytotoxic lymphocytes to kill target cells.
*Induction of the expression of IL-2 receptor on T-cells
*Stimulation of proliferation of antibody- producing B cells.
NCBI/Uniprot data below describe general gene information for IL2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
interleukin-2
NCBI Official Synonym Full Names
interleukin 2
NCBI Official Symbol
NCBI Official Synonym Symbols
IL-2; TCGF; lymphokine
  [Similar Products]
NCBI Protein Information
interleukin-2; aldesleukin; T cell growth factor; involved in regulation of T-cell clonal expansion
UniProt Protein Name
Interleukin-2
UniProt Synonym Protein Names
T-cell growth factor
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
IL-2; TCGF  [Similar Products]
UniProt Entry Name
IL2_HUMAN
NCBI Summary for IL2
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
UniProt Comments for IL2
IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family.

Protein type: Oncoprotein; Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q26-q27

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; interleukin-2 receptor binding; cytokine activity; kinase activator activity; glycosphingolipid binding; carbohydrate binding; kappa-type opioid receptor binding

Biological Process: positive regulation of isotype switching to IgG isotypes; negative regulation of heart contraction; natural killer cell activation; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; elevation of cytosolic calcium ion concentration; cell-cell signaling; negative regulation of protein amino acid phosphorylation; positive regulation of cell proliferation; protein kinase C activation; positive regulation of B cell proliferation; cell adhesion; T cell differentiation; positive regulation of interleukin-17 production; regulation of T cell homeostatic proliferation; positive regulation of regulatory T cell differentiation; positive regulation of immunoglobulin secretion; positive regulation of cell growth; positive regulation of interferon-gamma production; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; immune response; negative regulation of B cell apoptosis; positive regulation of inflammatory response; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with IL2 protein
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