NP_751950.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,233 Da
NCBI Official Full Name
interleukin-15 receptor subunit alpha isoform 2
NCBI Official Synonym Full Names
interleukin 15 receptor, alpha
NCBI Official Synonym Symbols
NCBI Protein Information
interleukin-15 receptor subunit alpha; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interleukin 15 receptor alpha isoform IC3; interleukin 15 receptor alpha isoform IC4; interleukin 15 receptor alpha isoform IC5; interleukin 15 receptor alpha isoform IC6; interleukin 15 receptor alpha isoform IC7; interleukin 15 receptor alpha isoform IC8
UniProt Protein Name
Interleukin-15 receptor subunit alpha
UniProt Synonym Gene Names
IL-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; sIL-15 receptor subunit alpha; sIL-15R-alpha; sIL-15RA [Similar Products]
UniProt Entry Name
I15RA_HUMAN
NCBI Summary for IL2Ralpha
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]
UniProt Comments for IL2Ralpha
IL15RA: High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 and SYK. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 10p15.1
Cellular Component: Golgi membrane; extracellular space; endoplasmic reticulum membrane; nuclear membrane; cytoplasmic vesicle membrane; integral to membrane
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; signal transducer activity
Biological Process: cell proliferation; cytokine and chemokine mediated signaling pathway; signal transduction
Research Articles on IL2Ralpha
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Pathways associated with IL2Ralpha elisa kit
Organs/Tissues associated with IL2Ralpha elisa kit
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