NP_032394.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted Molecular Mass: 26.3kDa Accurate Molecular Mass: 27kDa as determined by SDS-PAGE reducing conditions.
NCBI Official Full Name
interleukin-2 receptor subunit beta
NCBI Official Synonym Full Names
interleukin 2 receptor, beta chain
NCBI Official Synonym Symbols
p70; CD122; IL15Rbeta; Il-2Rbeta; IL-15Rbeta; Il-2/15Rbeta [Similar Products]
NCBI Protein Information
interleukin-2 receptor subunit beta
UniProt Protein Name
Interleukin-2 receptor subunit beta
UniProt Synonym Protein Names
High affinity IL-2 receptor subunit beta; p70-75; CD_antigen: CD122
UniProt Synonym Gene Names
NCBI Summary for IL2Rb
The interleukin 2 receptor is composed of alpha and beta subunits. The beta subunit encoded by this gene is very homologous to the human beta subunit and also shows structural similarity to other cytokine receptors. [provided by RefSeq, Jul 2008]
UniProt Comments for IL2Rb
IL2RB: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I. Belongs to the type I cytokine receptor family. Type 4 subfamily.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 15 E1|15 37.52 cM
Cellular Component: cell surface; external side of plasma membrane; integral component of membrane; membrane
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-2 binding; interleukin-2 receptor activity
Biological Process: cytokine-mediated signaling pathway; natural killer cell activation; negative regulation of apoptosis
Research Articles on IL2Rb
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Products associated with IL2Rb active protein
Pathways associated with IL2Rb active protein
Diseases associated with IL2Rb active protein
Organs/Tissues associated with IL2Rb active protein
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