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Il4 active protein :: Interleukin-4 protein (Il4) Active Protein

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Catalog # MBS969448
Unit / Price
Scan QR to view Datasheet
  0.005 mg (E-Coli)  /  $130 +1 FREE 8GB USB
  0.02 mg (E-Coli)  /  $225 +1 FREE 8GB USB
  0.1 mg (E-Coli)  /  $640 +1 FREE 8GB USB
  0.25 mg (E-Coli)  /  $1,095 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,675 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,470 +3 FREE 8GB USB
SDS-PAGE
Product Name

Interleukin-4 protein (Il4), Active Protein

Popular Item
Full Product Name

Recombinant Mouse Interleukin-4 protein (Il4) (Active)

Product Synonym Names
IL-4; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
21-140aa
Sequence
M+HIHGCDKN H LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S
3D Structure
ModBase 3D Structure for P07750
Host
E Coli
Purity/Purification
>=97% as determined by SDS-PAGE and HPLC. (lot specific)
Form/Format
Lyophilized
Species
Mus musculus (Mouse)
Biological Activity
Fully biologically active when compared to standard. The ED50 as determined by the dose-dependant prolifiration of Murine HT-2 cells is less then 2 ng/ml, corresponding to a Specific Activity of > 5 × 105 IU/mg.
Storage Buffer
0.2 um filtered, PBS, pH 7.4,lyophilized
Endotoxin
Less than 1.0 EU/ug as determined by LAL method.
Protein Note
Protein will be provided with aseptic processing and endotoxin removal.
Preparation and Storage
Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Active Protein Note
Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system.
Other Notes
Small volumes of Il4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Il4 active protein
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.

SDS-PAGE of Il4 active protein
Il4 active protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for Il4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
13.5 kDa
NCBI Official Full Name
interleukin-4
NCBI Official Synonym Full Names
interleukin 4
NCBI Official Symbol
NCBI Official Synonym Symbols
Il-4; BSF-1
  [Similar Products]
NCBI Protein Information
interleukin-4
UniProt Protein Name
Interleukin-4
UniProt Synonym Protein Names
B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor; Lymphocyte stimulatory factor 1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
Il-4; IL-4; BSF-1  [Similar Products]
UniProt Comments for Il4
IL4: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Belongs to the IL-4/IL-13 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11 B1.3|11 31.97 cM

Cellular Component: external side of plasma membrane; extracellular space

Molecular Function: cytokine activity

Biological Process: B cell activation; B cell costimulation; cholesterol metabolic process; defense response to protozoan; innate immune response in mucosa; microglial cell activation; myeloid dendritic cell differentiation; negative regulation of acute inflammatory response; negative regulation of chronic inflammatory response; negative regulation of macrophage activation; negative regulation of nitric oxide biosynthetic process; negative regulation of osteoclast differentiation; negative regulation of T cell activation; negative regulation of transcription, DNA-dependent; positive regulation of activated T cell proliferation; positive regulation of B cell activation; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of chemokine biosynthetic process; positive regulation of defense response to virus by host; positive regulation of immunoglobulin production; positive regulation of interleukin-10 production; positive regulation of interleukin-13 production; positive regulation of isotype switching to IgE isotypes; positive regulation of isotype switching to IgG isotypes; positive regulation of mast cell degranulation; positive regulation of MHC class II biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of T cell differentiation; positive regulation of T cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of STAT protein; regulation of immune response; regulation of inflammatory response; regulation of proton transport; T-helper 1 cell lineage commitment; T-helper 2 cell differentiation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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