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IL4 cdna clone

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Catalog # MBS1277375
Unit / Price
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
IL4 cdna clone
Product Name

IL4, cDNA Clone

Popular Item
Full Product Name

IL4 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgggtctca cctcccaact gcttccccct ctgttcttcc tgctagcatg tgccggcaac tttgtccacg gacacaagtg cgatatcacc ttacaggaga tcatcaaaac tttgaacagc ctcacagagc agaagactct gtgcaccgag ttgaccgtaa cagacatctt tgctgcctcc aagaacacaa ctgagaagga aaccttctgc agggctgcga ctgtgctccg gcagttctac agccaccatg agaaggacac tcgctgcctg ggtgcgactg cacagcagtt ccacaggcac aagcagctga tccgattcct gaaacggctc gacaggaacc tctggggcct ggcgggcttg aattcctgtc ctgtgaagga agccaaccag agtacgttgg aaaacttctt ggaaaggcta aagacgatca tgagagagaa atattcaaag tgttcgagct ga
OMIM
147780
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of IL4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for IL4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,797 Da
NCBI Official Full Name
Homo sapiens interleukin 4, mRNA
NCBI Official Synonym Full Names
interleukin 4
NCBI Official Symbol
NCBI Official Synonym Symbols
BSF1; IL-4; BCGF1; BSF-1; BCGF-1
  [Similar Products]
NCBI Protein Information
interleukin-4
UniProt Protein Name
Interleukin-4
UniProt Synonym Protein Names
B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
IL-4; BSF-1  [Similar Products]
UniProt Entry Name
IL4_HUMAN
NCBI Summary for IL4
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Comments for IL4
IL4: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Belongs to the IL-4/IL-13 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Cell cycle regulation; Motility/polarity/chemotaxis; Cytokine

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space

Molecular Function: cytokine activity; interleukin-4 receptor binding; protein binding

Biological Process: B cell differentiation; cellular defense response; chemotaxis; cholesterol metabolic process; connective tissue growth factor biosynthetic process; immune response; myeloid dendritic cell differentiation; negative regulation of apoptosis; negative regulation of osteoclast differentiation; negative regulation of transcription, DNA-dependent; positive regulation of B cell proliferation; positive regulation of interleukin-13 production; positive regulation of isotype switching to IgE isotypes; positive regulation of isotype switching to IgG isotypes; positive regulation of MHC class II biosynthetic process; positive regulation of T cell differentiation; positive regulation of T cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of immune response; regulation of isotype switching; regulation of phosphorylation; T-helper 2 type immune response

Disease: Stroke, Ischemic
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with IL4 cdna clone
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