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IL6R alpha recombinant protein

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Catalog # MBS538133
Unit / Price
  0.005 mg  /  $180 +1 FREE 8GB USB
IL6R alpha recombinant protein
Product Name

IL6R alpha, Recombinant Protein

Popular Item
Also Known As

IL6R alpha protein

Product Synonym Names
B cell stimulatory factor-2 protein; soluble IL-6 receptor alpha protein; IL-6; IL6; Interleukin 6R alpha protein; CD126 protein; IL-6R alpha protein; IL-6 protein; IL 6 protein; IL 6
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
352
Sequence
Region of IL6R protein correspond ing to amino acids LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQD.
OMIM
147880
3D Structure
ModBase 3D Structure for P08887
Host
Human
Purity/Purification
> 98% pure
Form/Format
Lyophilized from 1x PBS. Reconstitute in 1X PBS to a concentration of 0.1-1.0 mg/ml. When dissolved, dilute further into aqueous buffered solutions.
Concentration
5ug per vial (lot specific)
Protein Type
Recombinant
Biological Significance
IL6 mediates its biological effects through the type I IL6 receptor system that consists of two chains, IL6Ra and gp130. The IL6Ra chain is the binding component specific to IL6; while the gp130 only transmits signals of IL6 when bound to IL6Ra. The gp130 also can transmit signals from LIF, OSM, CNTF, IL11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL6 is composed of IL6Ra alone. IL6Ra is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL6Ra which consists of only the extracellular domain of the IL6Ra chain, acts as an agonist of IL6 activity at low concentrations.
Bioactivity
The ED50 was determined by its ability to intensify the IL-6 induced growth inhibition of Mouse M1 cells is approximately 5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
HEK cells
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of IL6R alpha recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IL6R alpha recombinant protein
Purified recombinant Human IL6R alpha protein
Applications Tested/Suitable for IL6R alpha recombinant protein
User optimized
NCBI/Uniprot data below describe general gene information for IL6R alpha. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37.6 kDa
NCBI Official Full Name
interleukin-6 receptor subunit alpha isoform 3
NCBI Official Synonym Full Names
interleukin 6 receptor
NCBI Official Symbol
NCBI Official Synonym Symbols
IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1
  [Similar Products]
NCBI Protein Information
interleukin-6 receptor subunit alpha
UniProt Protein Name
Interleukin-6 receptor subunit alpha
UniProt Synonym Protein Names
IL-6R 1; Membrane glycoprotein 80; gp80; CD_antigen: CD126
UniProt Gene Name
UniProt Synonym Gene Names
IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; gp80  [Similar Products]
UniProt Entry Name
IL6RA_HUMAN
NCBI Summary for IL6R alpha
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]
UniProt Comments for IL6R alpha
IL6R: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: extracellular space; basolateral plasma membrane; apical plasma membrane; plasma membrane; extracellular region; interleukin-6 receptor complex

Molecular Function: protein binding; protein homodimerization activity; enzyme binding; interleukin-6 binding; interleukin-6 receptor binding; ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity

Biological Process: positive regulation of smooth muscle cell proliferation; cytokine and chemokine mediated signaling pathway; negative regulation of collagen biosynthetic process; neutrophil mediated immunity; positive regulation of interleukin-6 production; positive regulation of leukocyte chemotaxis; defense response to Gram-negative bacterium; endocrine pancreas development; positive regulation of chemokine production; activation of NF-kappaB transcription factor; positive regulation of tyrosine phosphorylation of Stat3 protein; monocyte chemotaxis; positive regulation of osteoblast differentiation; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; positive regulation of MAPKKK cascade; response to cytokine stimulus; positive regulation of cell proliferation; negative regulation of interleukin-8 production; acute-phase response; hepatic immune response

Disease: Interleukin 6, Serum Level Of, Quantitative Trait Locus; Soluble Interleukin-6 Receptor, Serum Level Of, Quantitative Trait Locus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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