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ILGFBP1 recombinant protein

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Catalog # MBS538329
Unit / Price
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  0.002 mg  /  $370 +1 FREE 8GB USB
  0.01 mg  /  $980 +1 FREE 8GB USB
ILGFBP1 recombinant protein
Product Name

ILGFBP1, Recombinant Protein

Full Product Name

ILGFBP1 protein

Product Synonym Names
ILGFBP-1; hIGFBP-1 protein; PP12 protein; ILGFBP1; ILGFBP 1; ILGFBP-1 protein; AFBP protein; ILGFBP 1 protein; IGF-BP25 protein; IGF-Binding Protein 1 protein; IBP-1 protein; IGFBP-1 protein; Insulin Like Growth Factor Binding Protein 1 protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
146730
3D Structure
ModBase 3D Structure for P08833
Host
Human
Purity/Purification
> 98% pure
Form/Format
Supplied as a lyophilized powder. Reconstitute in 20mM CH3COOH at the stock concentration of not less than 0.1mg/ml.
Protein Type
Recombinant
Biological Significance
IGFBP1 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Bioactivity
Inhibition of IGF-I stimulated proliferation of NUC-1 cells: IC50 ~ 100 ng/ml Inhibition of serum-induced stimulation of DNA synthesis in chick embryo fibroblast primary cultures: IC50 (1% serum) ~300 ng/ml.
Expression System
E Coli
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of ILGFBP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ILGFBP1 recombinant protein
Purified recombinant Human ILGFBP1 protein
Applications Tested/Suitable for ILGFBP1 recombinant protein
User optimized
NCBI/Uniprot data below describe general gene information for ILGFBP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25.3 kDa
NCBI Official Full Name
insulin-like growth factor-binding protein 1
NCBI Official Synonym Full Names
insulin-like growth factor binding protein 1
NCBI Official Symbol
IGFBP1  [Similar Products]
NCBI Official Synonym Symbols
AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1
  [Similar Products]
NCBI Protein Information
insulin-like growth factor-binding protein 1
UniProt Protein Name
Insulin-like growth factor-binding protein 1
UniProt Synonym Protein Names
Placental protein 12; PP12
UniProt Gene Name
IGFBP1  [Similar Products]
UniProt Synonym Gene Names
IBP1; IBP-1; IGF-binding protein 1; IGFBP-1; PP12  [Similar Products]
UniProt Entry Name
IBP1_HUMAN
NCBI Summary for ILGFBP1
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
UniProt Comments for ILGFBP1
IGFBP1: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7p12.3

Cellular Component: extracellular space; extracellular region

Molecular Function: insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding

Biological Process: cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; regulation of insulin-like growth factor receptor signaling pathway; unfolded protein response; tissue regeneration; insulin receptor signaling pathway; signal transduction; positive regulation of cell growth
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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