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IMPDH2 cdna clone

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Catalog # MBS1273729
Unit / Price
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
IMPDH2 cdna clone
Product Name

IMPDH2, cDNA Clone

Popular Item
Full Product Name

IMPDH2 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggccgact acctgattag tgggggcacg tcctacgtgc cagacgacgg actcacagca cagcagctct tcaactgcgg agacggcctc acctacaatg actttctcat tctccctggg tacatcgact tcactgcaga ccaggtggac ctgacttctg ctctgaccaa gaaaatcact cttaagaccc cactggtttc ctctcccatg gacacagtca cagaggctgg gatggccata gcaatggcgc ttacaggcgg tattggcttc atccaccaca actgtacacc tgaattccag gccaatgaag ttcggaaagt gaagaaatat gaacagggat tcatcacaga ccctgtggtc ctcagcccca aggatcgcgt gcgggatgtt tttgaggcca aggcccggca tggtttctgc ggtatcccaa tcacagacac aggccggatg gggagccgct tggtgggcat catctcctcc agggacattg attttctcaa agaggaggaa catgactgtt tcttggaaga gataatgaca aagagggaag acttggtggt agcccctgca ggcatcacac tgaaggaggc aaatgaaatt ctgcagcgca gcaagaaggg aaagttgccc attgtaaatg aagatgatga gcttgtggcc atcattgccc ggacagacct gaagaagaat cgggactacc cactagcctc caaagatgcc aagaaacagc tgctgtgtgg ggcagccatt ggcactcatg aggatgacaa gtataggctg gacttgctcg cccaggctgg tgtggatgta gtggttttgg actcttccca gggaaattcc atcttccaga tcaatatgat caagtacatc aaagacaaat accctaatct ccaagtcatt ggaggcaatg tggtcactgc tgcccaggcc aagaacctca ttgatgcagg tgtggatgcc ctgcgggtgg gcatgggaag tggctccatc tgcattacgc aggaagtgct ggcctgtggg cggccccaag caacagcagt gtacaaggtg tcagagtatg cacggcgctt tggtgttccg gtcattgctg atggaggaat ccaaaatgtg ggtcatattg cgaaagcctt ggcccttggg gcctccacag tcatgatggg ctctctcctg gctgccacca ctgaggcccc tggtgaatac ttcttttccg atgggatccg gctaaagaaa tatcgcggta tgggttctct cgatgccatg gacaagcacc tcagcagcca gaacagatat ttcagtgaag ctgacaaaat caaagtggcc cagggagtgt ctggtgctgt gcaggacaaa gggtcaatcc acaaatttgt cccttacctg attgctggca tccaacactc atgccaggac attggtgcca agagcttgac ccaagtccga gccatgatgt actctgggga gcttaagttt gagaagagaa cgtcctcagc ccaggtggaa ggtggcgtcc atagcctcca ttcgtatgag aagcggcttt tctga
OMIM
146691
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of IMPDH2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for IMPDH2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,805 Da
NCBI Official Full Name
Homo sapiens IMP (inosine monophosphate) dehydrogenase 2, mRNA
NCBI Official Synonym Full Names
inosine monophosphate dehydrogenase 2
NCBI Official Symbol
IMPDH2  [Similar Products]
NCBI Official Synonym Symbols
IMPD2; IMPDH-II
  [Similar Products]
NCBI Protein Information
inosine-5'-monophosphate dehydrogenase 2
UniProt Protein Name
Inosine-5'-monophosphate dehydrogenase 2
UniProt Synonym Protein Names
IMPDH-II
UniProt Gene Name
IMPDH2  [Similar Products]
UniProt Synonym Gene Names
IMP dehydrogenase 2; IMPD 2; IMPDH 2  [Similar Products]
UniProt Entry Name
IMDH2_HUMAN
NCBI Summary for IMPDH2
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
UniProt Comments for IMPDH2
IMPDH2: a rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.

Protein type: EC 1.1.1.205; Nucleotide Metabolism - purine; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: cytoplasm; cytosol; membrane; nucleus; peroxisomal membrane

Molecular Function: IMP dehydrogenase activity; nucleotide binding; protein binding

Biological Process: GTP biosynthetic process; purine ribonucleoside monophosphate biosynthetic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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