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IRF4 blocking peptide

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Catalog # MBS151926
Unit / Price
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  0.05 mg  /  $140 +1 FREE 8GB USB
Western Blot (WB)
Product Name

IRF4, Blocking Peptide

Popular Item
Full Product Name

IRF4 Peptide

Product Synonym Names
MUM1; LSIRF; NF-EM5; MUM1; Interferon regulatory factor 4; Lymphocyte-specific interferon regulatory factor; IRF-4; interferon regulatory factor 4
Antibody/Peptide Pairs
IRF4 peptide (MBS151926) is used for blocking the activity of IRF4 antibody (MBS151469)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
phenotype 601900
3D Structure
ModBase 3D Structure for Q15306
Form/Format
Liquid
Concentration
200 ug/mL (lot specific)
Species
Human
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
16 amino acids near the carboxy terminus of human IRF4.
Preparation and Storage
Store IRF4 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of IRF4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for IRF4 blocking peptide
Blocking (BL)
Application Notes for IRF4 blocking peptide
IRF4 peptide is used for blocking the activity of IRF4 antibody.

Western Blot (WB) of IRF4 blocking peptide
Western blot analysis of TYW4 in rat brain tissue lysate with TYW4 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
IRF4 blocking peptide Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for IRF4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,644 Da
NCBI Official Full Name
interferon regulatory factor 4 isoform 1
NCBI Official Synonym Full Names
interferon regulatory factor 4
NCBI Official Symbol
NCBI Official Synonym Symbols
MUM1; LSIRF; SHEP8; NF-EM5
  [Similar Products]
NCBI Protein Information
interferon regulatory factor 4; multiple myeloma oncogene 1; lymphocyte-specific interferon regulatory factor
UniProt Protein Name
Interferon regulatory factor 4
UniProt Synonym Protein Names
Lymphocyte-specific interferon regulatory factor; LSIRF; Multiple myeloma oncogene 1; NF-EM5
UniProt Gene Name
UniProt Synonym Gene Names
MUM1; IRF-4; LSIRF  [Similar Products]
UniProt Entry Name
IRF4_HUMAN
NCBI Summary for IRF4
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
UniProt Comments for IRF4
IRF4: Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Interacts with SPIB and DEF6. Not induced by interferons. Lymphoid cells. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 6p25-p23

Cellular Component: nucleoplasm; membrane; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; sequence-specific DNA binding; protein-lysine N-methyltransferase activity; transcription factor binding; transcription factor activity

Biological Process: transcription, DNA-dependent; T cell activation; positive regulation of interleukin-2 biosynthetic process; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; regulation of T-helper cell differentiation; myeloid dendritic cell differentiation; defense response to protozoan; peptidyl-lysine methylation; positive regulation of interleukin-10 biosynthetic process; positive regulation of interleukin-4 biosynthetic process; positive regulation of interleukin-13 biosynthetic process; negative regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA binding

Disease: Skin/hair/eye Pigmentation, Variation In, 8
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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