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IRGM blocking peptide

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Catalog # MBS151917
Unit / Price
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  0.05 mg  /  $140 +1 FREE 8GB USB
IRGM blocking peptide
Product Name

IRGM, Blocking Peptide

Full Product Name

IRGM Peptide

Product Synonym Names
IFI1; IRGM1; LRG47; LRG-47; IFI1; Immunity-related GTPase family M protein; Immunity-related GTPase family M protein 1; immunity-related GTPase family, M
Antibody/Peptide Pairs
IRGM peptide (MBS151917) is used for blocking the activity of IRGM antibody (MBS150804)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 612278
3D Structure
ModBase 3D Structure for A1A4Y4
Form/Format
Liquid
Concentration
200 ug/mL (lot specific)
Species
Human
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
17 amino acids near the amino terminus of human IRGM.
Preparation and Storage
Store IRGM peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of IRGM blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for IRGM blocking peptide
Blocking (BL)
Application Notes for IRGM blocking peptide
IRGM peptide is used for blocking the activity of IRGM antibody.
NCBI/Uniprot data below describe general gene information for IRGM. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,142 Da
NCBI Official Full Name
IRGM protein
NCBI Official Synonym Full Names
immunity-related GTPase family, M
NCBI Official Symbol
NCBI Official Synonym Symbols
IFI1; IRGM1; LRG47; LRG-47
  [Similar Products]
NCBI Protein Information
immunity-related GTPase family M protein; LRG-47-like protein; interferon-inducible protein 1; immunity-related GTPase family, M1; LPS-stimulated RAW 264.7 macrophage protein 47 homolog
UniProt Protein Name
Immunity-related GTPase family M protein
UniProt Synonym Protein Names
Immunity-related GTPase family M protein 1; Interferon-inducible protein 1; LPS-stimulated RAW 264.7 macrophage protein 47 homolog; LRG-47
UniProt Gene Name
UniProt Synonym Gene Names
IFI1; IRGM1; LRG47; LRG-47  [Similar Products]
UniProt Entry Name
IRGM_HUMAN
NCBI Summary for IRGM
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010]
UniProt Comments for IRGM
IRGM: Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility. Defects in IRGM are the cause of susceptibility to inflammatory bowel disease type 19 (IBD19). A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Belongs to the interferon-inducible GTPase family.

Protein type: EC 3.6.5.-; Hydrolase; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: Golgi membrane; phagocytic vesicle membrane; cell projection; phagocytic cup

Molecular Function: GTP binding; hydrolase activity

Biological Process: autophagy; innate immune response; inflammatory response

Disease: Mycobacterium Tuberculosis, Susceptibility To; Inflammatory Bowel Disease 19
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with IRGM blocking peptide
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