NP_000467.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,635 Da
NCBI Official Full Name
adenylate kinase isoenzyme 1
NCBI Official Synonym Full Names
adenylate kinase 1
NCBI Protein Information
adenylate kinase isoenzyme 1; AK 1; myokinase; ATP:AMP phosphotransferase; ATP-AMP transphosphorylase 1; adenylate monophosphate kinase
UniProt Protein Name
Adenylate kinase isoenzyme 1
UniProt Synonym Protein Names
ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; Adenylate monophosphate kinase; Myokinase
UniProt Synonym Gene Names
UniProt Entry Name
KAD1_HUMAN
NCBI Summary for KAD1
Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008]
UniProt Comments for KAD1
AK1: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD). Belongs to the adenylate kinase family.
Protein type: Kinase, other; EC 2.7.4.3; EC 2.7.4.6; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 9q34.1
Cellular Component: cytoplasm; plasma membrane; cytosol; outer dense fiber
Molecular Function: nucleoside diphosphate kinase activity; adenylate kinase activity; ATP binding
Biological Process: ATP metabolic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; nucleoside triphosphate biosynthetic process; nucleoside diphosphate phosphorylation; ADP biosynthetic process; AMP metabolic process; cell cycle arrest
Disease: Adenylate Kinase Deficiency, Hemolytic Anemia Due To
Research Articles on KAD1
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Pathways associated with anti-KAD1 antibody
Diseases associated with anti-KAD1 antibody
Organs/Tissues associated with anti-KAD1 antibody
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