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Kcnj1 recombinant protein :: ATP-sensitive inward rectifier potassium channel 1 (Kcnj1) Recombinant Protein

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Catalog # MBS717525
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Kcnj1 recombinant protein
Product Name

ATP-sensitive inward rectifier potassium channel 1 (Kcnj1), Recombinant Protein

Popular Item
Also Known As

Recombinant Rat ATP-sensitive inward rectifier potassium channel 1 (Kcnj1)

Product Synonym Names
Recombinant ATP-sensitive inward rectifier potassium channel 1 (Kcnj1); ATP-sensitive inward rectifier potassium channel 1; ATP-regulated potassium channel ROM-K Inward rectifier K(+) channel Kir1.1 KAB-1 Potassium channel, inwardly rectifying subfamily J
Product Synonym Gene Name
Kcnj1; Romk1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-391
Sequence Length
391
Sequence
MGASERSVFR VLIRALTERM FKHLRRWFIT HIFGRSRQRA RLVSKEGRCN IEFGNVDAQS RFIFFVDIWT TVLDLKWRYK MTVFITAFLG SWFLFGLLWY VVAYVHKDLP EFYPPDNRTP CVENINGMTS AFLFSLETQV TIGYGFRFVT EQCATAIFLL IFQSILGVII NSFMCGAILA KISRPKKRAK TITFSKNAVI SKRGGKLCLL IRVANLRKSL LIGSHIYGKL LKTTITPEGE TIILDQTNIN FVVDAGNENL FFISPLTIYH IIDHNSPFFH MAAETLSQQD FELVVFLDGT VESTSATCQV RTSYVPEEVL WGYRFVPIVS KTKEGKYRVD FHNFGKTVEV ETPHCAMCLY NEKDARARMK RGYDNPNFVL SEVDETDDTQ M
Chromosome Location
Chromosome: 8; NC_005107.3 (33453597..33454750). Location: 8q21
3D Structure
ModBase 3D Structure for P35560
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rattus norvegicus (Rat)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Kcnj1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Kcnj1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,963 Da[Similar Products]
NCBI Official Full Name
ATP-sensitive inward rectifier potassium channel 1
NCBI Official Synonym Full Names
potassium inwardly-rectifying channel, subfamily J, member 1
NCBI Official Symbol
Kcnj1  [Similar Products]
NCBI Official Synonym Symbols
Kcnj; ROMK1
  [Similar Products]
NCBI Protein Information
ATP-sensitive inward rectifier potassium channel 1; KAB-1; kir1.1; K+ channel protein; inward rectifier K(+) channel Kir1.1; ATP-regulated potassium channel ROM-K; Potassium inwardly-rectifying channel subfamily J; potassium channel, inwardly rectifying subfamily J member 1
UniProt Protein Name
ATP-sensitive inward rectifier potassium channel 1
UniProt Synonym Protein Names
ATP-regulated potassium channel ROM-K; Inward rectifier K(+) channel Kir1.1; KAB-1; Potassium channel, inwardly rectifying subfamily J member 1
UniProt Gene Name
Kcnj1  [Similar Products]
UniProt Synonym Gene Names
Romk1  [Similar Products]
UniProt Entry Name
IRK1_RAT
NCBI Summary for Kcnj1
potassium channel involved in K+ secretion in the renal distal nephron [RGD, Feb 2006]
UniProt Comments for Kcnj1
Function: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.

Enzyme regulation: Inhibited by WNK3

By similarity.

Subunit structure: Interacts with SGK1 and SLC9A3R2/NHERF2

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein. Note: Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane

By similarity.

Tissue specificity: Mainly in kidney (renal cortex, medulla and papilla). In the brain, found in the cortex and the hippocampus.

Post-translational modification: Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane

By similarity.

Sequence similarities: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily. [View classification]
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with Kcnj1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >163 publications with Kcnj1 and Kidney
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