NP_000881.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,668 Da
NCBI Official Full Name
G protein-activated inward rectifier potassium channel 4
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily J member 5
NCBI Official Synonym Symbols
CIR; GIRK4; KATP1; LQT13; KIR3.4 [Similar Products]
NCBI Protein Information
G protein-activated inward rectifier potassium channel 4
UniProt Protein Name
G protein-activated inward rectifier potassium channel 4
UniProt Synonym Protein Names
Cardiac inward rectifier; CIR; Heart KATP channel; Inward rectifier K(+) channel Kir3.4; IRK-4; KATP-1; Potassium channel, inwardly rectifying subfamily J member 5
UniProt Synonym Gene Names
NCBI Summary for KCNJ5/GIRK4
This gene encodes an integral membrane protein which belongs to one of seven subfamilies of inward-rectifier potassium channel proteins called potassium channel subfamily J. The encoded protein is a subunit of the potassium channel which is homotetrameric. It is controlled by G-proteins and has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Naturally occurring mutations in this gene are associated with aldosterone-producing adenomas. [provided by RefSeq, Aug 2017]
UniProt Comments for KCNJ5/GIRK4
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
Research Articles on KCNJ5/GIRK4
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Products associated with KCNJ5/GIRK4 elisa kit
Pathways associated with KCNJ5/GIRK4 elisa kit
Diseases associated with KCNJ5/GIRK4 elisa kit
Organs/Tissues associated with KCNJ5/GIRK4 elisa kit
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